Evidence map›Paper›PMID 42824369›Full record

ReviewFrontiers in immunology2026

Vancomycin-induced immune hemolytic anemia: a case report and literature review.

Ruochen Zhang, Yanan Wang, Zhongying Wang, Yu Tao, Sujuan Zheng, Shenghao Xu, Ling Wang, Dong Xiang, Jiang Wu

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruochen Zhang *Department of Blood Transfusion, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yanan Wang *Department of Blood Transfusion, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhongying WangBlood Group Reference Laboratory, Shanghai Institute of Blood Transfusion, Shanghai Blood Center, Shanghai, China.
Yu TaoDepartment of Blood Transfusion, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Sujuan ZhengDepartment of Blood Transfusion, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shenghao XuDepartment of Blood Transfusion, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ling WangDepartment of Blood Transfusion, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Dong XiangBlood Group Reference Laboratory, Shanghai Institute of Blood Transfusion, Shanghai Blood Center, Shanghai, China.
Jiang WuDepartment of Blood Transfusion, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-induced immune hemolytic anemia (DIIHA) is a rare but potentially life-threatening adverse drug reaction. Although more than 150 drugs have been reported to induce DIIHA, vancomycin, a glycopeptide antibiotic widely used in clinical practice, is rarely associated with hemolysis, making it prone to underdiagnosis or misdiagnosis. This article reports a case of vancomycin-induced DIIHA in a 64-year-old female patient after right revision knee arthroplasty (RKA). This study investigated the serological tests associated with vancomycin and tracks drug antibody titers through longitudinal monitoring during clinical diagnosis and treatment. Additionally, a literature review identified and summarized five previously reported cases of vancomycin-induced immune hemolytic anemia. Clinicians should maintain a high index of suspicion for hemolysis associated with vancomycin, including its use in bone cement. Early recognition, prompt withdrawal of the offending agent, and transfusion support are imperative for improving patient outcomes with DIIHA.

Indexed as

Anemia, Hemolytic, AutoimmuneAnti-Bacterial AgentsVancomycinAnemia, HemolyticArthroplasty, Replacement, KneeFemaleHemolysisHumansMiddle AgedAnti-Bacterial AgentsVancomycindiagnosis and treatment of hemolysisdrug antibody titersdrug-induced immune hemolytic anemia (DIIHA)serological testvancomycin

Identifiers

PMID42824369
PMCPMC13627317

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.