ArticleFrontiers in immunology2026
Immunological dynamics of memory T cells in gram-negative septic shock patients: a prospective clinical study.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Septic shock induced by Gram-negative bacilli can lead to severe immune dysfunction. The dysfunction and reprogramming of memory T cells are closely involved in the immunosuppressive state of septic shock. This study aimed to investigate the dynamic changes of memory T cells in such patients and their association with clinical outcomes. Methods: This study is a prospective clinical research. Thirty-five patients with Gram-negative septic shock were enrolled and classified into survival and non-survival groups. Peripheral blood samples were obtained on admission, day 2 and day 7 after admission, and patients were stratified into survival and death groups based on 28-day survival status. Flow cytometry was performed to analyze the proportions of lymphocyte subsets as well as CD4 Results: Compared with survivors, non-survivors showed significantly reduced counts of CD8 Conclusion: Patients with Gram-negative septic shock exhibited early elevation in the proportion and activity of CD8
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