ArticleJournal of oral microbiology2026
The association between the oral microbiome and oral Kaposi's sarcoma-associated herpesvirus (KSHV) shedding is modified by age and HIV status in a rural Ugandan cohort.
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Background: Kaposi's sarcoma-associated herpesvirus (KSHV) spreads through saliva. KSHV shedding is intermittent, suggesting individual-level factors affect reactivation. Objective: Identify associations between oral microbiome and KSHV shedding. Design: Oral mouthwash samples from 67 KSHV-seropositive participants (ages 4-78) were tested for KSHV DNA by qPCR and microbiome composition via 16S rRNA V4 region sequencing (Illumina MiSeq, Earth Microbiome Project protocols). Samples were selected on age, self-reported HIV status, and KSHV shedding. Alpha and beta diversity and relative abundances at species, genus and phylum levels were compared by KSHV shedding status. Analyses of KSHV shedding and the oral microbiome were stratified by HIV status ( Results: Neither alpha nor beta diversity differed by KSHV shedding status. Shedders had higher differential abundance of Conclusions: Differences in oral microbiome were associated with KSHV shedding and possibly modified by age and HIV status. Future research should consider the multifactorial nature of the oral environment and KSHV reactivation.
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