Evidence map›Paper›PMID 42825349›Full record

ReviewInternational journal of molecular medicine2026

Novel insights into the role of the renal interstitial microenvironment in Randall's plaque formation (Review).

Jialiang Wang, Zhangcheng Liao, Minghui Liu, Yizhou Wang, Yu Cui, Hequn Chen, Feng Zeng, Zewu Zhu

Abstract readReview
In one paragraph

Review in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jialiang WangDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Zhangcheng LiaoDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Minghui LiuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Yizhou WangDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Yu CuiDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Hequn ChenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Feng ZengDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Zewu ZhuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Randall's plaque (RP) consists of subepithelial hydroxyapatite (HAP) deposits within renal papillae and provides a well‑established attachment substrate for a subset of idiopathic calcium oxalate (CaOx) kidney stones. However, RP has traditionally been viewed as a passive mineral surface onto which crystals accrete, with comparatively less focus on the cellular and molecular events that build the plaque itself. The renal papillary interstitium has been indicated as a dynamic microenvironment that undergoes molecular remodeling during plaque‑associated mineralization. The present review aimed to organize the current evidence regarding interconnected processes that may overlap

Indexed as

Cellular MicroenvironmentKidneyKidney CalculiKidney MedullaAnimalsCalcium OxalateDurapatiteHumansCalcium OxalateDurapatitecalcium oxalate nephrolithiasisosteogenic reprogrammingRandall's plaquerenal interstitial microenvironmentrenal papilla

Identifiers

PMID42825349
PMCPMC13637563

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.