Evidence map›Paper›PMID 42826055›Full record

ArticleeLife2026

The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome.

Beth A Shen, Kyle L Asfahl, Bentley Lim, Savannah K Bertolli, Samuel S Minot, Matthew C Radey, Kelsi M Penewit, Billy Ngo, Stephen J Salipante, Christopher D Johnston and 3 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Beth A ShenDepartment of Microbiology, University of Washington, Seattle, United States.
Kyle L AsfahlMicrobial Interactions & Microbiome Center, University of Washington, Seattle, United States.
Bentley LimDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, United States.
Savannah K BertolliDepartment of Microbiology, University of Washington, Seattle, United States.
Samuel S MinotBioinformatics Core, Fred Hutchinson Cancer Center, Seattle, United States.
Matthew C RadeyDepartment of Microbiology, University of Washington, Seattle, United States.
Kelsi M PenewitDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, United States.
Billy NgoDepartment of Microbiology, University of Washington, Seattle, United States.
Stephen J SalipanteDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, United States.
Christopher D JohnstonDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center Houston, Houston, United States.
S Brook PetersonDepartment of Microbiology, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0003-2648-0965
Andrew L GoodmanDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, United States.ORCID https://orcid.org/0000-0001-7599-3471
Joseph D MougousDepartment of Microbiology, University of Washington, Seattle, United States.ORCID https://orcid.org/0000-0002-5417-4861

Funding

Causes and consequences of interpersonal microbial variationR35GM118159 · NIGMS · YALE UNIVERSITY · PI Andrew L Goodman · 2016 to 2026
$5.6M
The SyngenicDNA and μPOET Platform: Overcoming Innate Barriers to Genetic Engineering in Bacteria.R01DE027850 · NIDCR · FRED HUTCHINSON CANCER RESEARCH CENTER · PI JOHNSTON, CHRISTOPHER D · 2017 to 2021
$4.9M
Toxin neutralization to functionally dissect interbacterial antagonism in the gut microbiomeF32AI164853 · NIAID · UNIVERSITY OF WASHINGTON · PI SHEN, BETH A · 2022 to 2024
$218k
NIAID NIH HHS F32 AI164853NIDCR NIH HHS R01 DE027850NIGMS NIH HHS R35 GM118159NIH HHS DE027850NIH HHS F32 AI164853NIH HHS R35GM118159
6 · The paper itself

Abstract

Bacteria inhabiting the mammalian gut coexist in dense communities where contact-dependent antagonism mechanisms are widespread. The type VI secretion system (T6SS) is an interbacterial toxin delivery pathway prevalent among gut Bacteroidales, yet its function in naturally evolved microbiomes remains poorly defined. Here, we examine the role of the T6SS in

Indexed as

BacteroidesGastrointestinal MicrobiomeType VI Secretion SystemsAnimalsMiceType VI Secretion SystemsBacteroidesinfectious diseasemicrobiologymicrobiometype VI secretion system

Identifiers

PMID42826055
PMCPMC13633076

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.