Evidence map›Paper›PMID 42827204›Full record

ArticleThe EMBO journal2026

Leptin-sensitive hypothalamic Lepr+/Glp1r+ neurons limit hyperphagia and weight gain in diet-induced obesity.

Dylan M Belmont-Rausch, Benedicte Schultz Kapel, Abigail J Tomlinson, Chao Ding, Allison M Duensing, Bernd Coester, Cecilie Vad Mathiesen, Leonie Cabot, Jenny M Brown, Charlotte Høy Kruse and 7 more

Abstract read
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In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Dylan M Belmont-RauschNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Benedicte Schultz Kapel *Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Abigail J Tomlinson *Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Chao DingResearch Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, Cologne, Germany.
Allison M DuensingDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Bernd CoesterNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Cecilie Vad MathiesenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Leonie CabotResearch Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, Cologne, Germany.
Jenny M BrownNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5072-4491
Charlotte Høy KruseNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0009-0005-5147-9984
Shad HassanNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Elizabeth HeatonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Christoffer ClemmensenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2456-9667
Michael W SchwartzDiabetes and Obesity Center of Excellence, Department of Medicine, University of Washington at South Lake Union, Seattle, WA, USA.
Henning FenselauResearch Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, Cologne, Germany.ORCID http://orcid.org/0000-0001-7136-9751
Martin G Myers *Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. mgmyers@umich.edu.ORCID http://orcid.org/0000-0001-9468-2046
Tune H Pers *Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. tune.pers@sund.ku.dk.ORCID http://orcid.org/0000-0003-0207-4831

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Thermoregulatory circuits that regulate feedingR01DK124238 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, Tune Hannes Pers · 2020 to 2026
$3.9M
Foundation for the National Institutes of Health (FNIH) P30DK020572Foundation for the National Institutes of Health (FNIH) R01DK124238Foundation for the National Institutes of Health (FNIH) R01DK56731Ministry of Science, Innovation and Higher Education | Danish Agency for Higher Education and Science (UFS) 8045-00091BNovo Nordisk Fonden (NNF) NNF18CC0033668Novo Nordisk Fonden (NNF) NNF18CC0034900Novo Nordisk Fonden (NNF) NNF23SA0084103
6 · The paper itself

Abstract

Despite loss of responsiveness to exogenous leptin in obesity, endogenous leptin continues to restrain feeding, although the neural substrates that remain sensitive and mediate this effect remain unknown. Combining spatial transcriptomics with single-nucleus RNA sequencing in mice with diet-induced obesity (DIO), we here show that while most hypothalamic leptin receptor (Lepr)-positive neurons minimally respond to elevated leptin, a single subpopulation defined by glucagon-like peptide-1 receptor (Glp1r) co-expression retains robust leptin sensitivity. These Lepr

Identifiers

PMID42827204

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.