ArticleFrontiers in cellular and infection microbiology2026
The predictive value of aGAPSS score combined with clinical factors for thrombosis in systemic lupus erythematosus.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study evaluated the predictive value of antiphospholipid antibodies (aPLs) combined with the adjusted global antiphospholipid syndrome score (aGAPSS) for thrombosis in hospitalized systemic lupus erythematosus (SLE) patients. Methods: A retrospective analysis included 309 SLE patients (65 with in-hospital thrombosis, 244 without). Demographic, clinical, and serological data were collected. Least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression identified independent risk factors. A combined predictive model was constructed and internally validated using bootstrap. Results: Patients with thrombosis were older, had higher smoking prevalence, LA ratio, and aGAPSS (all Conclusion: Integrating aGAPSS with clinical factors provides good discriminative ability for in-hospital thrombosis risk stratification in hospitalized SLE patients, offering a practical tool that may inform surveillance intensity and prophylactic consideration.
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