ReviewFrontiers in pharmacology2026
Review Areca Thirteen Pill (GY-13) for depression: a ConPhyMP-Informed critical review of material definition, pharmacological evidence, and translational Heyi-neuroplasticity-stress hypotheses.
Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous summaries of GY-13 have lacked transparent literature-search methods, reproducible material definitions, chemical-characterization status, or critical evidence grading, limiting their scientific utility. Objective: This review critically evaluates what the published GY-13 literature shows and does not show regarding antidepressant pharmacology, material reproducibility, clinical evidence, and safety. It also reformulates the Heyi-Neuroplasticity-Stress (HNS) framework as a testable translational hypothesis rather than as a confirmed mechanism. Methods: This critical scoping review was reported using a PRISMA-informed approach, with PRISMA-ScR, the Four Pillars of Best Practice in Ethnopharmacology, and ConPhyMP used as reporting and interpretive frameworks. Searches were rerun on 3 June 2026 in PubMed/MEDLINE and CNKI, supplemented by public bibliographic records and citation checking. Thirty records were identified; after deduplication and screening, 12 studies or contextual records were retained. The review was not prospectively registered, screening and extraction were not performed by two independent reviewers, and no validated design-specific risk-of-bias tool was applied. These limitations preclude designation as a fully systematic review. Results: The available evidence supports the possibility that GY-13 affects depression-related behavioral and molecular endpoints in stress-based animal models, including cAMP/PKA/CREB/BDNF signaling, HPA-axis feedback, monoamine signaling, inflammatory-oxidative pathways, and chemokine-axis findings. However, the reproducibility of these findings is limited by incomplete reporting of batch identity, voucher/authentication data, manufacturing details, HPLC/UPLC or LC-MS fingerprints, marker-metabolite quantification, dose-response structure, and randomization/blinding. Human evidence remains preliminary and insufficient for definitive clinical-efficacy claims. Conclusion: GY-13 is best treated as a hypothesis-generating multi-component intervention requiring chemically defined batches, strict ConPhyMP documentation, independent preclinical replication, and well-powered clinical trials with standardized safety monitoring. The HNS framework may guide future biomarker-enriched research only if tested prospectively with transparent materials and methods.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.