ArticleInfection and drug resistance2026
Antibiotic Resistance Trends and Prescribing Patterns in Pediatric Non-Typhoidal
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Non-typhoidal Methods: The study included children with microbiologically confirmed NTS enteritis with available antibiotic susceptibility data. Resistance rates for 11 antibiotics were calculated, and temporal trends were analysed using the Cochran-Armitage trend test. MDR was defined as resistance to three or more antibiotic classes. Treatment concordance was assessed by comparing the empiric antibiotic class with in vitro susceptibility results. Results: Of 486 records reviewed, 422 children were included. Infants under one year included 69.4% of cases. Conclusion: Ampicillin/sulbactam resistance rose markedly, while ciprofloxacin resistance decreased in our cohort. The change may be related to reduced fluoroquinolone prescribing and broader antimicrobial-use policy shifts in our institute, although this cannot be confirmed without institutional prescribing data. One in four children showed MDR isolates. Discordance was highest for ceftriaxone-based regimens, indicating that empiric antibiotic selection should be guided by local institutional susceptibility surveillance rather than a fixed choice of agent. Ongoing monitoring of institutional resistance is vital to support antibiotic stewardship in pediatric NTS enteritis.
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