ArticleACS pharmacology & translational science2026
Neuropeptide Y Receptor Binding Profiles of Endogenous Ligands in the Presence and Absence of Sodium: A Panoramic View.
Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neuropeptide Y (NPY) receptors (YRs) play a key regulatory role in essential human physiological processes such as bone metabolism, feeding, anxiolysis, and pain modulation, making them potential therapeutic targets. Nonetheless, radiochemical ligand binding studies needed for the development of therapeutics actings at YRs, have been conducted inconsistently in the presence or absence of sodium, the latter representing a nonphysiological-like condition that may lead to inaccurate interpretations. As such, this study aimed to provide an in-depth overview of the binding affinities of endogenous YR agonists, namely NPY, peptide YY (PYY), and pancreatic polypeptide (PP), to the various YR subtypes, Y
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