Evidence map›Paper›PMID 42828557›Full record

ArticleJournal of cancer research and clinical oncology2026

Longer-term response to SARS-CoV-2 vaccination after allogeneic blood stem cell transplantation.

Carl C Crodel, Laura Gork, Wibke Göpel, Paul Linke, Konrad Sinn, Jenny Miethke, Andreas Hochhaus, Inken Hilgendorf

Abstract read
In one paragraph

Article in Journal of cancer research and clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carl C CrodelInnere Medizin 2, Hämatologie Und Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany. carl.crodel@med.uni-jena.de.ORCID https://orcid.org/0009-0000-2160-1452
Laura GorkInnere Medizin 2, Hämatologie Und Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.
Wibke GöpelInnere Medizin 2, Hämatologie Und Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.
Paul LinkeInnere Medizin 2, Hämatologie Und Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.
Konrad SinnInnere Medizin 2, Hämatologie Und Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.
Jenny MiethkeInnere Medizin 2, Hämatologie Und Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.
Andreas HochhausInnere Medizin 2, Hämatologie Und Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.
Inken HilgendorfInnere Medizin 2, Hämatologie Und Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRecipients of allogeneic haematopoietic stem cell transplantation (alloHSCT) are at increased risk of COVID-19 and lower vaccine immunogenicity. This study assessed vaccine immunogenicity and safety in these patients.

methodsWe analyzed the serological response after the 2nd and 3rd SARS-CoV-2 vaccination as well as potential factors influencing this response. Data were obtained from internal hospital records. In addition, a questionnaire was used to evaluate the vaccination status, vaccination side effects and the course of expired COVID-19 disease.

resultsIn total, 114 patients (median age 62, range 27 - 70) were enrolled between July and September 2022, with 55 females (48.2%). One year later a follow up was conducted. Most patients (89.4%) were vaccinated at least twice, 66.7% received three vaccinations, and 10.5% refused the vaccination. The mRNA vaccines were predominantly used. Most patients responded and reached SARS-CoV-2 spike IgG titers after the 2nd (81.8%) or 3rd (96.1%) vaccination. Patients vaccinated within 24 months of alloHSCT had significantly lower anti-spike IgG levels than those vaccinated later (p=0.017). Common side effects included arm pain (34%), swelling (14%), and limb pain (17%).

conclusionVaccination was feasible and well-tolerated in alloHSCT recipients. Timing of vaccination influenced immune response, with a stronger response after the 3rd dose compared to the initial series.

Indexed as

COVID-19COVID-19 VaccinesHematopoietic Stem Cell TransplantationImmunogenicity, VaccineSARS-CoV-2AdultAgedAntibodies, ViralFemaleHumansMaleMiddle AgedTransplantation, HomologousVaccinationAntibodies, ViralCOVID-19 VaccinesAllogeneic transplantation,InfectionsSARS-COV-2Vaccination

Identifiers

PMID42828557
PMCPMC13634024

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.