Evidence map›Paper›PMID 42830610›Full record

ArticlePigment cell & melanoma research2026

Allele-Specific GNAQ Q209 Mutations Reveal Context-Dependent Oncogenic Programs in Uveal Melanoma.

Vinesh Jarajapu, Sathya Neelature Sriramareddy, Nicol Mecozzi, Kaizhen Wang, Florian A Karreth, Xiaonan Xu

Abstract read
In one paragraph

Article in Pigment cell & melanoma research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vinesh JarajapuDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Sathya Neelature SriramareddyDepartment of Tumor Microenvironment and Metastasis, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID https://orcid.org/0000-0001-9189-3956
Nicol MecozziDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID https://orcid.org/0000-0001-6161-5074
Kaizhen WangDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID https://orcid.org/0000-0001-6033-7041
Florian A KarrethDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID https://orcid.org/0000-0002-2350-9809
Xiaonan XuDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID https://orcid.org/0000-0002-7366-580X

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Elucidating the role of circPMS1 in melanoma metastasis.F99CA305524 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Nicol Mecozzi · 2025 to 2026
$82k
Congressionally Directed Medical Research Programs ME230182H. Lee Moffitt Cancer Center and Research Institute P30CA076292Melanoma Research Alliance 935329Melanoma Research Foundation 1068914NCI NIH HHS 1F99CA305524-01NCI NIH HHS F99 CA305524NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

Uveal melanoma (UM) is driven by activating GNAQ/GNA11 mutations, predominantly at the hotspot Q209 residue. However, the functional impact of distinct GNAQ Q209 substitutions on downstream signaling and malignant progression remains unclear. Using immune-competent, multistep UM mouse models combining eye-restricted mutant GNAQ with BAP1 loss and MYC activation, we directly compared GNAQ

Indexed as

AllelesCarcinogenesisGTP-Binding Protein alpha Subunits, Gq-G11MelanomaMutationUveal NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationHumansMiceSignal TransductionUveal MelanomaYAP-Signaling ProteinsGNAQ protein, humanGTP-Binding Protein alpha Subunits, Gq-G11YAP-Signaling Proteins

Identifiers

PMID42830610
PMCPMC13635764

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.