Evidence map›Paper›PMID 42830680›Full record

ArticlePhysiological reports2026

Supraphysiological ascorbic acid infusion attenuates cerebrovascular dysfunction in middle-aged and older adults.

Theodore M DeConne, Faria Sanjana, Elizabeth M Habash, Kevin P Decker, Wendy Nichols, Joshua C Hobson, Nicholas A Rizzi, Christopher R Martens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Theodore M DeConneDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.ORCID https://orcid.org/0000-0002-9704-6499
Faria SanjanaDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
Elizabeth M HabashDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
Kevin P DeckerDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
Wendy NicholsDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
Joshua C HobsonDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
Nicholas A RizziDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
Christopher R MartensDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.ORCID https://orcid.org/0000-0003-0578-2948

Funding

Vascular Consequences of Duchenne Muscular DystrophyP20GM113125 · NIGMS · UNIVERSITY OF DELAWARE · PI FANCHER, IBRA · 2016 to 2025
$23.3M
NAD+ Therapy for Improving Memory & Cerebrovasular Function in Patients with MCIK01AG054731 · NIA · UNIVERSITY OF DELAWARE · PI MARTENS, CHRISTOPHER · 2017 to 2021
$723k
HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20 GM113125HHS | NIH | National Institute on Aging (NIA) K01 AG054731NIA NIH HHS K01 AG054731NIGMS NIH HHS P20 GM113125
6 · The paper itself

Abstract

Cerebrovascular endothelial function can be assessed by measuring the shear-mediated dilation or cerebrovascular reactivity (CVR) of the internal carotid artery (ICA) in response to transient hypercapnia (30 s). ICA CVR is blunted with aging; however, it is not known whether age-related reductions in ICA CVR are influenced by antioxidant-responsive mechanisms. The purpose of this study was to determine whether infusion of the antioxidant, ascorbic acid (AA) restores ICA CVR in middle-aged and older (MA/O) adults. We also examined the effect of AA on middle cerebral artery (MCA) CVR to sustained (3-min) hypercapnia. We hypothesized that MA/O adults would exhibit lower cerebrovascular function compared to young (Y) adults, and that infusion of AA would improve cerebrovascular function in MA/O adults, whereas infusion of saline (SAL) would not. The primary analytic sample included nine Y adults (25 ± 2 years) and nineteen (65 ± 6 years) MA/O adults, with analyzable data varying by outcome. ICA CVR was measured using high-resolution duplex ultrasound, and MCA CVR was measured using transcranial Doppler ultrasound. AA infusion improved ICA CVR and MCA CVR in MA/O adults but had no effect in Y adults. These findings suggest that age-related impairments in cerebrovascular function may be partly attributable to mechanisms responsive to acute, supraphysiological AA administration.

Indexed as

AgingAntioxidantsAscorbic AcidCerebrovascular CirculationCerebrovascular DisordersAdultAgedCarotid Artery, InternalFemaleHumansHypercapniaMaleMiddle AgedMiddle Cerebral ArteryAntioxidantsAscorbic Acidagingantioxidantcerebral blood flowcerebrovascular functionendothelial function

Identifiers

PMID42830680
PMCPMC13635807

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.