Evidence map›Paper›PMID 42831056›Full record

ArticleEClinicalMedicine2026

Effect of a wearable-based individualised multidomain lifestyle intervention on cognitive and physical function in older adults at risk of decline (INSPIOR): a single-centre, open-label, randomised controlled trial.

Keisuke Sakurai, Ryo Tanaka, Joseph Ledsam, Izumi Shiraishi, Hiroyasu Kasahara, Saya Anzai, Miwa Watanabe, Momoko Funakawa, Saori Shimada, Tatsuya Goto and 17 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06135740 (Impact of Notifications on Nutrition, Sleep, and Physical Activity on Intellectual Function and Muscle Mass in OldeR Adults), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06135740 nacompletednot on this map

Impact of Notifications on Nutrition, Sleep, and Physical Activity on Intellectual Function and Muscle Mass in OldeR Adults (INSPIOR)

TypeinterventionalSponsorTokyo UniversityRan2023 to 2025Enrolled355ConditionsCognition Disorders in Old Age, Cognitive Function, Frailty/Sarcopenia, MCIArmsFitbit wearing, with notification for sleep, activity and nutrition based fitbit data, Routine care
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Keisuke SakuraiDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Ryo TanakaDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Joseph LedsamGoogle, Mountain View, CA, USA.
Izumi ShiraishiDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Hiroyasu KasaharaDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Saya AnzaiDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Miwa WatanabeDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Momoko FunakawaDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Saori ShimadaDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Tatsuya GotoDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Riki KawabataDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Keiko MurasakinoDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Tomoko KawauraDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Noriko InamuraUrban Design Center Kashiwanoha (UDCK), Kashiwa, Japan.
Ko KanetaCommunity Health Promotion Laboratory, Mitsui Fudosan, Kashiwa, Japan.
Satoru KobayashiCommunity Health Promotion Laboratory, Mitsui Fudosan, Kashiwa, Japan.
Toshiyuki NomuraPlanning Group, Kashiwanoha Urban Planning and Development Department, Mitsui Fudosan, Kashiwa, Japan.
Nori KarasawaResearch and Development Center, NH Foods, Tsukuba, Japan.
Takashi MatsumotoResearch and Development Center, NH Foods, Tsukuba, Japan.
Tomoki TairaTechnology Development Office, NH Foods, Joso, Japan.
Toshihiro IshiguroTechnology Development Office, NH Foods, Joso, Japan.
Kazuyuki KudoCustomer Service Department, NH Foods, Shinagawa, Japan.
Matthew J ThompsonGoogle, Mountain View, CA, USA.
Hiroki KayamaGoogle, Mountain View, CA, USA.
Yukihiro SugawaraResearch and Development Center, NH Foods, Tsukuba, Japan.
Shin'ichi WarisawaDepartment of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Tatsuhiro HisatsuneDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Multidomain lifestyle programmes are the leading preventive approach to cognitive decline, but they rely on intensive face-to-face delivery that is hard to scale. We assessed whether an automated, wearable-based multidomain programme of activity, sleep, and optional nutrition prompts changed cognitive and physical function in at-risk older adults. Methods: INSPIOR was a 6-month, single-centre, open-label, randomised controlled trial in Kashiwa, Japan. Adults aged 65-92 years with low body-mass index, pre-frailty, frailty, or sarcopenia-related decline were randomly assigned 1:1, in permuted blocks of four and without stratification, to the Fitbit-based intervention or an assessment-only control; allocation was not concealed and outcome assessors were not masked. Co-primary outcomes were the Montreal Cognitive Assessment (MoCA), Trail Making Test (TMT), and skeletal muscle mass index (SMI), with no pre-specified hierarchy or multiplicity adjustment; analyses used intention-to-treat analysis of covariance with multiple imputation. This trial was registered with UMIN-CTR, UMIN000052707, and ClinicalTrials.gov, NCT06135740. Findings: Between Nov 8, 2023, and Jul 31, 2024, 355 participants were randomly assigned to the intervention group (n = 178) or control group (n = 177); all were analysed. Adjusted between-group differences were 0·58 MoCA points (95% CI 0·03-1·13; p = 0·039; Holm-adjusted p = 0·12), 0·16 s (-5·07 to 5·40; p = 0·95) for TMT-A, 5·59 s (-3·88 to 15·05; p = 0·25) for TMT-B, and -0·01 kg/m Interpretation: The intervention was associated with a small difference in a global cognitive screening score that did not survive multiplicity adjustment and is of uncertain clinical significance; the other two showed none. Larger, longer, masked trials are needed. Funding: University of Tokyo-NH Foods Collaborative Research Programme, Google, Mitsui Fudosan.

Indexed as

Cognitive ageingCognitive functionMultidomain lifestyle interventionOlder adultsWearable device

Identifiers

PMID42831056
PMCPMC13634265

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.