Path-dependent viscoelastic-hyperelastic response of brain tissue under multistage shear loading.

Hadi Nosrati, Mehdi Shafieian, Kurosh Darvish

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Article in Medical & biological engineering & computing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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3 authors.

Hadi NosratiDepartment of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.

Mehdi ShafieianDepartment of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. shafieian@aut.ac.ir.

Kurosh DarvishDepartment of Mechanical Engineering, Temple University, Philadelphia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancing computational models of repetitive traumatic brain injury (rTBI) requires understanding how prior loading alters the mechanical response of brain tissue. However, most previous studies have relied on single-stage loading or limited preconditioning protocols that do not capture path-dependent behavior. To bridge this gap, multistage simple shear experiments were performed on 14 bovine brain specimens. Successive ramp-and-hold and cyclic loading protocols examined the effects of loading mode, strain amplitude, and loading sequence within the reported sub-damaging loading range. Mechanical behavior was quantified using the shear modulus (μ) and Prony-series viscoelastic parameters (g₁-g₃, g

Indexed as

Brain injury biomechanicsConstitutive modellingLoading path-dependenceShear testing

Identifiers

PMID42832160

DOI10.1016/j.jbiomech.2021.110260

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.