ArticleNPJ Parkinson's disease2026
Behavioral changes preceded by subthalamic nucleus activity alterations in a progressive macaque model of Parkinson's disease.
Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Parkinson's disease (PD) is diagnosed after motor symptoms appear, although non-motor symptoms emerge years earlier. Following years of pharmacological treatment, high-frequency stimulation (HFS) of the subthalamic nucleus (STN), a key hub in goal-directed behaviors, can be proposed. While HFS-STN reliably improves motor symptoms, it does not specifically address non-motor symptoms. Clarifying how STN dysfunction contributes to these symptoms could improve stimulation strategies. Here, we longitudinally recorded STN local field potentials in two macaques performing a demanding task during chronic low-dose MPTP treatment. This progressive model, evolving from an asymptomatic stage to motivational, cognitive, and motor deficits, enabled detailed characterization of non-motor stages preceding motor impairment. Each stage was associated with distinct electrophysiological alterations, including early loss of reward-related theta activity, followed by disappearance of decision-related theta oscillations and later reduction of movement-related beta rebound. In the stable parkinsonian stage, stimulation of different STN territories produced complementary behavioral effects: dorsal HFS improved motor performance, whereas ventral low-frequency stimulation alleviated motivational deficits. These findings reveal a temporal relationship between STN dysfunction and symptom onset and support site- and frequency-specific stimulation strategies to address motor and non-motor symptoms in PD.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.