Evidence map›Paper›PMID 42835072›Full record

ArticleBioactive materials2027

Targeted inhibition of inflammatory liver macrophages with a multifunctional nanoparticle ameliorates metabolic dysfunction-associated steatohepatitis.

Kaige Chen, Lulu Wang, Liang Liu, Chad A Arledge, Hui-Kuan Lin, Jingmei Lin, Amyn A Habib, Dawen Zhao

Abstract read
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaige ChenDepartment of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Lulu WangDepartment of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Liang LiuDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Chad A ArledgeDepartment of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Hui-Kuan LinDepartment of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.
Jingmei LinDepartment of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Amyn A HabibDepartment of Neurology, University of Texas Southwestern Medical Center and VA North Texas Medical Center, Dallas, TX, 75390, USA.
Dawen ZhaoDepartment of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.

Funding

Intrapleural immunotherapeutic nanoparticles for MPE treatmentR01CA264102 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LU, YONG, ZHAO, DAWEN · 2021 to 2025
$2.3M
Bimodal EGFR signaling in glioblastomaR01NS119225 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI AMYN HABIB · 2022 to 2026
$2.0M
The kinase inhibited RTK forms a scaffold to drive therapeutic resistance in cancerR01CA299152 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI AMYN HABIB · 2025 to 2026
$898k
NCI NIH HHS R01 CA264102NCI NIH HHS R01 CA299152NINDS NIH HHS R01 NS119225
6 · The paper itself

Abstract

Despite metabolic dysfunction-associated steatohepatitis (MASH) being a significant global health concern, there are few effective ways to prevent or treat MASH. Evidence from preclinical and clinical studies suggests that inflammatory polarization of Kupffer cells (KCs) and infiltration of monocyte-derived macrophages (MDMs) in liver macrophages play an essential role in the initiation and progression of MASH. Herein, we reported a liposomal nanoparticle (NP-OMg) that targets suppressive oligodeoxynucleotide (sODN) and magnesium ions (Mg

Identifiers

PMID42835072
PMCPMC13634900

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.