Evidence map›Paper›PMID 42835397›Full record

ArticleMedComm2026

TRIM28 Increases RFC4 Protein Expression to Promote Triple-Negative Breast Cancer Progression.

Cheng Guo, Li Liu, Lixiang Sun, Litong Liu, Han Wei, Yutong Yan, Fei Yu, Guangming Fu, Xianning Dong, Ceshi Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cheng GuoDepartment of Pathology The Affiliated Hospital of Qingdao University Qingdao Shandong China.
Li LiuDepartment of Breast and Thyroid Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing China.
Lixiang SunDepartment of Pathology The Affiliated Hospital of Qingdao University Qingdao Shandong China.
Litong LiuThe Third People's Hospital of Datong City Shanxi Province Shanxi China.
Han WeiDepartment of Pathology School of Basic Medicine Qingdao University Qingdao Shandong China.
Yutong YanDepartment of Pathology The Affiliated Hospital of Qingdao University Qingdao Shandong China.
Fei YuDepartment of Pathology School of Basic Medicine Qingdao University Qingdao Shandong China.
Guangming FuDepartment of Pathology The Affiliated Hospital of Qingdao University Qingdao Shandong China.
Xianning DongDepartment of Pathology The Affiliated Hospital of Qingdao University Qingdao Shandong China.
Ceshi ChenYunnan Key Laboratory of Breast Cancer Precision Medicine Academy of Biomedical Engineering Kunming Medical University Kunming China.
Chengqin WangDepartment of Pathology The Affiliated Hospital of Qingdao University Qingdao Shandong China.ORCID https://orcid.org/0000-0002-3540-4385

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Replication factor C subunit 4 (RFC4) dysregulation has been implicated in tumor progression and poor prognosis across multiple cancer types. Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options and poor outcomes, underscoring the need for effective therapeutic targets. However, the role of RFC4 in TNBC progression and metastasis remains unclear. In the present study, integrated bioinformatics analyses, together with validation in 80 clinical TNBC samples, showed that RFC4 was markedly upregulated in TNBC. In vitro functional assays and experiments in nude mouse models further demonstrated that elevated RFC4 expression contributed to TNBC progression (

Indexed as

ras‐associated protein 1replication factor C subunit 4tripartite motif‐containing 28triple‐negative breast cancerubiquitination

Identifiers

PMID42835397
PMCPMC13635811

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.