ReviewFrontiers in veterinary science2026
Endocrine-metabolic modulators in sperm biotechnology: cross-species mechanisms and translational priorities.
Review in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocrine-metabolic dysregulation is increasingly recognized as a determinant of male reproductive competence. Its implications for sperm biotechnology remain under-integrated. This review advances a systems framework in which insulin resistance (IR), adipokine imbalance, and vitamin D-calcium signaling converge on core sperm functional modules, i.e., membrane lipid architecture, mitochondrial efficiency, redox stability, and capacitation kinetics. Across species, metabolic strain is associated with oxidative vulnerability and altered substrate handling - amplifying damage during cooling, cryopreservation, and sorting. Adipokines emerge as biomarkers of energy-inflammatory state and as functional modulators within seminal plasma and at the sperm surface, with dose- and context-dependent effects on motility and survival. The vitamin D axis, through Ca
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.