Evidence map›Paper›PMID 42836905›Full record

ArticleAnnals of biomedical engineering2026

Aortic Longitudinal Stretch and Recoil Affect Cerebral Perfusion: Insights from a Physiologically Accurate In-Vitro Experiment Model.

Haojie Geng, Arian Aghilinejad, Coskun Bilgi, Daniel A Nation, Niema M Pahlevan

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Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Haojie GengDepartment of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA, USA.
Arian AghilinejadDepartment of Bioengineering, University of California, Merced, CA, USA.
Coskun BilgiDepartment of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA, USA.
Daniel A NationLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Niema M PahlevanDepartment of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA, USA. pahlevan@usc.edu.ORCID http://orcid.org/0000-0001-7498-0396

Funding

National Science Foundation 2145890
6 · The paper itself

Abstract

purposeBlood transport in the cardiovascular system depends on the interaction between cardiac dynamics and arterial function. While the left ventricle is the primary driver of flow, recent evidence suggests that longitudinal stretch and recoil of the aorta may generate a wave-pumping effect. However, the contribution of this mechanism to cerebral blood flow remains unclear.

methodIn this study, we developed a physiologically relevant in-vitro model to isolate the effects of longitudinal aortic motion in the absence of left ventricular pumping. Aortic phantoms with varying stiffness (quantified by pulse wave velocity [PWV]) were subjected to controlled physiologically accurate cyclic stretching across a range of frequencies and amplitudes. Carotid flow waveforms were measured, and a mechanistic model was formulated based on two governing parameters: an elastic energy term associated with longitudinal stretch and a dimensionless wave condition number characterizing wave dynamics.

resultOur results suggest that longitudinal stretch-recoil generated a wave-pumping effect in the carotid artery, producing bidirectional net mean flow depending on wave conditions. The magnitude and direction of flow were strongly dependent on PWV, stretching frequency, and amplitude. Furthermore, the proposed mechanistic model showed strong agreement with the measured experimental data (

conclusionOur findings demonstrate that aortic longitudinal stretch and recoil can actively contribute to cerebral blood flow through a wave-based pumping mechanism. This provides a mechanistic link among the heart, aorta, and cerebral perfusion.

Indexed as

AortaBiofluid dynamicsCerebral blood flowHemodynamicsWave dynamics

Identifiers

PMID42836905

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