ArticleNeurology2026
Quantitative Relationship Between Lumipulse G Measures of pTau217 in Plasma and the Temporal Cortex.
Article in Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
13 authors.
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Abstract
BACKGROUND AND
objectivesPhosphorylated tau217 (pTau217) plasma assays have shown high diagnostic accuracy for Alzheimer disease (AD). However, validation of plasma pTau217 as a direct marker of brain-based pTau pathology requires understanding of its quantitative relationship with cortical pTau217. The primary objective of this postmortem validation study was to determine the quantitative relationship of plasma pTau217 levels and the pTau217/β-amyloid (Aβ)
methodsIn this retrospective study, patients with dementia were recruited from an academic memory clinic (University Hospitals Leuven) based on the joint availability of an antemortem plasma sample and postmortem brain tissue. An N-terminal pTau217 (pTau217
resultsThirty-two patients with dementia (mean age 66 [SD 10] years, 38% female) were included, of which 19 had an AD diagnosis and 13 had a diagnosis of frontotemporal lobar degeneration with either TDP-43 or tau inclusions, as determined at autopsy. Plasma pTau217 DISCUSSION: Plasma pTau217
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