In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
17 authors.
Pinqi Wang *Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK.ORCID 0009-0007-1160-1206 Xuan Zhang *Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4276-6464 Laura Jenkins *School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Carl von Hallerstein *Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.ORCID 0009-0003-6608-3603 Jonathan D ColburnDepartment of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.
Rowan IvesDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK.
Vincent B LuscombeSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK.
Sara MarsangoSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Listiana OktaviaDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK.
Arun RajaDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK.
David R GreavesSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK.ORCID 0000-0003-2856-9410 Graeme MilliganSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Graeme.Milligan@glasgow.ac.uk.ORCID 0000-0002-6946-3519 Cheng ZhangDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. chengzh@pitt.edu.ORCID 0000-0001-9042-4007 Irina G TikhonovaSchool of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland, UK. i.tikhonova@qub.ac.uk.ORCID 0000-0002-6228-9431 Angela J RussellDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK. angela.russell@chem.ox.ac.uk.ORCID 0000-0003-3610-9369 Funding
Biotechnology and Biological Sciences Research Council BB/R007101/1Biotechnology and Biological Sciences Research Council BB/T000562/1British Heart Foundation RG/15/10/23915British Heart Foundation RG/15/10/31485Marie Curie 101026581RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) UKRI3574Wellcome Trust 218514/Z/19/Z
6 · The paper itselfAbstract
Biased signaling in G protein-coupled receptors offers therapeutic promise, yet rational design of biased ligands remains challenging due to limited mechanistic understanding. Here, we report a molecular basis for controlling signaling bias at the immunometabolic receptor GPR84. We identify three structurally-matched ligands (OX04529, OX04954, and OX04539) with varying steric profiles that exhibit comparable G
Indexed as
Receptors, G-Protein-CoupledSignal Transductionbeta-ArrestinsCryoelectron MicroscopyGTP-Binding Protein alpha Subunits, Gi-GoHEK293 CellsHumansLigandsMolecular Dynamics Simulationbeta-ArrestinsGPR84 protein, humanGTP-Binding Protein alpha Subunits, Gi-GoLigandsReceptors, G-Protein-Coupled
Identifiers
PMID42838941
PMCPMC13642346
What Socratic holds
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