Evidence map›Paper›PMID 42839251›Full record

ArticleVeterinary research2026

Chicken cathelicidin-3 protected mice from avian pathogenic Escherichia coli infection mediated by triggering chemokine CCL3 pathway.

Luyao Jiang, Fan Yang, Jiayan Wu, Zhengliang Li, Xiemin Zhu, Hao Pan, Shaotong Zhang, Haochun Pan, Hang Wang, Jingting Yao and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Luyao JiangCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Fan YangCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Jiayan WuCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Zhengliang LiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Xiemin ZhuCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Hao PanCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Shaotong ZhangCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Haochun PanCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Hang WangCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Jingting YaoCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Ping YanCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Qingqing GaoCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Changchao HuanCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
Song GaoCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China. gsong@yzu.edu.cn.ORCID https://orcid.org/0000-0002-4814-2353
Xinan JiaoJiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China.
Xiufan LiuCollege of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.

Funding

National Key Research and Development Program of China 2021YFD1800404National Natural Science Foundation of China 32373011National Program for High Technology Research and Development in China grant number 2003 AA 222141Priority Academic Program Development of Jiangsu Higher Education Institutions PAPDthe 111 Project D18007 D18007
6 · The paper itself

Abstract

Host defense peptides (HDPs) possess both direct bacteriocidal and immunomodulatory activities. In this study, chicken cathelicidin-1 (cCATH-1) and chicken cathelicidin-3 (cCATH-3) were selected based on their markedly different minimum inhibitory concentrations (MICs) against avian pathogenic Escherichia coli (APEC) strains, with MICs of cCATH-1 being 4- to 16-fold lower than those of cCATH-3. However, following intraperitoneal challenge with APEC strain E058 (4 × 10⁶ CFU/mouse), 80% of cCATH-3 treated mice survived while 20% of cCATH-1 treated mice survived. Flow cytometry (FC) revealed significantly lower peripheral blood Ly6C

Indexed as

Antimicrobial Cationic PeptidesCathelicidinsChemokine CCL3ChickensEscherichia coliEscherichia coli InfectionsPoultry DiseasesAnimalsMacrophages, PeritonealMiceMicrobial Sensitivity TestsAntimicrobial Cationic PeptidesCathelicidinsChemokine CCL3CMAP27 protein, chickenavian pathogenic Escherichia colichicken cathelicidin-3Host defense peptidesmacrophagesmouse

Identifiers

PMID42839251
PMCPMC13640183

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.