Evidence map›Paper›PMID 42840583›Full record

ArticleBiochemistry and biophysics reports2026

Cereblon promotes influenza A virus replication through AMPK ubiquitination.

Thu Ha Nguyen, Dong Ju Lee, Mahmoud Soliman, Muhammad Sharif, Myra Hosmillo, Hyung-Jun Kwon, Seong-Hun Jeong, Dae-Eun Cheong, Hae-Rang Seo, Sunwoo Lee and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Thu Ha NguyenHost-Directed Antiviral Research Center, Chonnam National University, Gwangju, 61186, Republic of Korea.
Dong Ju LeeHost-Directed Antiviral Research Center, Chonnam National University, Gwangju, 61186, Republic of Korea.
Mahmoud SolimanDepartment of Pathology & Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
Muhammad SharifHost-Directed Antiviral Research Center, Chonnam National University, Gwangju, 61186, Republic of Korea.
Myra HosmilloDivision of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Hyung-Jun KwonFunctional Biomaterial Research Center, Korea Research Institute of Bioscience & Biotechnology, Jeongeup-si, Jeollabuk-do, 56212, Republic of Korea.
Seong-Hun JeongFunctional Biomaterial Research Center, Korea Research Institute of Bioscience & Biotechnology, Jeongeup-si, Jeollabuk-do, 56212, Republic of Korea.
Dae-Eun CheongHost-Directed Antiviral Research Center, Chonnam National University, Gwangju, 61186, Republic of Korea.
Hae-Rang SeoHost-Directed Antiviral Research Center, Chonnam National University, Gwangju, 61186, Republic of Korea.
Sunwoo LeeDepartment of Chemistry, Chonnam National University, Gwangju, 61186, Republic of Korea.
Don-Kyu KimDepartment of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju, 61186, Republic of Korea.
Chul-Seung ParkSchool of Life Sciences and Cell Dynamics Research Center and National Leading Research Laboratory of Ion Channels, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Hueng-Sik ChoiSchool of Biological Sciences and Technology, Chonnam National University, Gwangju, 61186, Republic of Korea.
Tae-Il JeonDepartment of Animal Science, Chonnam National University, Gwangju, 61186, Republic of Korea.
Ian G GoodfellowDivision of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Kyoung-Oh ChoHost-Directed Antiviral Research Center, Chonnam National University, Gwangju, 61186, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza A and B viruses (IAV and IBV) continually threaten global health, with IAV posing a risk of emerging pandemics. Rapid viral evolution makes current treatments less effective, highlighting the urgent need for broad-spectrum antivirals. Targeting host factors essential for viral replication may offer a highly promising broad-spectrum antiviral strategy. In this context, cereblon (CRBN), a substrate adaptor of the CRL4 E3 ubiquitin ligase complex, is found to promote both IAV and IBV replication as a key pro-viral host factor. Mechanistically, CRBN targets and degrades AMP-activated protein kinase (AMPK) via the proteasome. This CRBN-driven degradation shifts the metabolism of infected cells toward anabolism, promoting lipid droplet (LD) formation and creating a microenvironment conducive to viral replication. Genetic depletion or inhibition of CRBN stabilizes AMPK, significantly reduces LD formation, and effectively suppresses the replication of various IAV and IBV strains

Indexed as

AMPK ubiquitinationAnabolismCereblonInfluenza A virusLipogenic reprogrammingProviral

Identifiers

PMID42840583
PMCPMC13640024

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.