Evidence map›Paper›PMID 42840929›Full record

ReviewFrontiers in immunology2026

Spontaneous organ-specific eye autoimmune disease resulting from two engineered gene mutations compromising immune tolerance.

Mianmian Yin, Mark S Anderson, Clifford A Lowell, Anthony L DeFranco

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mianmian YinDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.
Mark S AndersonDiabetes Center, University of California, San Francisco, San Francisco, CA, United States.
Clifford A LowellDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, United States.
Anthony L DeFrancoDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, United States.

Funding

Monogenic Diabetes: Next Generation Diagnosis, Treatment and ComplicationsR01DK104942 · NIDDK · UNIVERSITY OF CHICAGO · PI GREELEY, SIRI ATMA W., PHILIPSON, LOUIS H. · 2016 to 2024
$4.7M
Thymic medullary epithelial cell turnover and control of immune toleranceR37AI097457 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mark S Anderson · 2017 to 2026
$4.0M
NIAID NIH HHS R37 AI097457NIDDK NIH HHS R01 DK104942
6 · The paper itself

Abstract

In order to address the question of how genetic compromises in multiple immune tolerance mechanisms might confer susceptibility to autoimmune disease development, we have bred together a partial loss of function in Aire, which is important for central tolerance of T cells, with a deficiency of the intracellular protein tyrosine kinase Lyn, which is important for function of inhibitory receptors of dendritic cells, B lymphocytes, and myeloid cells. These

Indexed as

Autoimmune DiseasesImmune ToleranceMutationRetinitisUveitisAIRE ProteinAnimalsDisease Models, AnimalLoss of Function MutationMiceAIRE ProteinAire protein, mouseAIREautoimmunityLynT cellTCRtransgenicuveitis

Identifiers

PMID42840929
PMCPMC13639950

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.