ArticleInfection and drug resistance2026
A Novel Erg3 T208Is Substitution Associated with Reduced Fluconazole and Voriconazole Susceptibility in Clinical
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: Antifungal susceptibility testing of clinical isolates was performed using the broth microdilution method in accordance with CLSI M27-A4 guidelines. Whole-genome sequencing (WGS) and Sanger sequencing were applied to screen for putative resistance-associated genetic mutations, with a focus on the key ergosterol biosynthesis genes Results: All four clinical isolates exhibited a putative resistance phenotype to fluconazole and voriconazole, with significantly higher minimum inhibitory concentrations (MICs) compared with the wild-type strain. A novel Conclusion: This is the first study to identify an association between the Erg3 T208I substitution and putative cross-resistance to fluconazole and voriconazole in
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