In one paragraphArticle in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
27 authors.
Jie YangJiangxi Provincial Key Laboratory of Respiratory Diseases; Jiangxi Institute of Respiratory Diseases; Jiangxi Clinical Research Center for Respiratory Diseases; Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.ORCID 0000-0003-3047-9051 Zhikai ZengJiangxi Provincial Key Laboratory of Respiratory Diseases; Jiangxi Institute of Respiratory Diseases; Jiangxi Clinical Research Center for Respiratory Diseases; Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.ORCID 0009-0001-0595-3690 Hui YinDepartment of Thoracic Surgery, The First Affiliated Hospital of Shaoyang University, Shaoyang 422000, China.ORCID 0009-0002-0598-4216 Xiaoning YangInstitute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.ORCID 0009-0007-3958-4487 Xuan ZhouDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0009-0001-9614-4003 Wen ZhengMedical and Radiation Oncology, Department of the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.ORCID 0009-0005-5434-468X Qian ZhuDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0001-6277-0965 Jiaqi LiuDepartment of Burn, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0009-0004-6391-7454 Zhihua KangLaboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200025, China.ORCID 0000-0001-8153-8846 Chengyuan WangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200032, China.ORCID 0000-0002-8605-0716 Bentong YuJiangxi Provincial Key Laboratory of Respiratory Diseases; Jiangxi Institute of Respiratory Diseases; Jiangxi Clinical Research Center for Respiratory Diseases; Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.ORCID 0000-0001-6396-1931 Funding
"Double Thousand Talents Program" of Jiangxi Province jxsg2023201025National Key Research and Development Program of China 2022YFA1302803National Key Research and Development Program of China 2023YFC2508604Shanghai East Hospital DFRC2024011
6 · The paper itselfAbstract
Xeroderma pigmentosum group A (XPA) serves as a core nucleotide excision repair (NER) factor essential for the repair process triggered by UV irradiation. Lactylation, a newly identified post-translational modification, plays a key role in tumorigenesis and cancer progression. Herein, we discovered that XPA was lactylated in the DNA-binding domain by the acyl-transferase KAT5. In addition, UV irradiation promoted XPA lactylation, thereby increasing the chromatin recruitment of XPA and NER. However, the mutation of XPA to a lactylation-deficient form impeded XPA chromatin recruitment under UV irradiation, impaired NER, and rendered cancer cells hypersensitive to UV irradiation. Our data demonstrate that the lactylation of XPA plays a crucial role in NER and reveals the link between metabolic reprogramming and DNA damage repair induced by UV irradiation.
Indexed as
DNA DamageDNA RepairProtein Processing, Post-TranslationalUltraviolet RaysXeroderma Pigmentosum Group A ProteinChromatinExcision RepairHistone AcetyltransferasesHumansChromatinHistone AcetyltransferasesXeroderma Pigmentosum Group A ProteinXPA protein, human
Identifiers
PMID42841231
PMCPMC13643169
What Socratic holds
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