Evidence map›Paper›PMID 42842684›Full record

ArticleScience advances2026

Rapid protamine evolution suppresses meiotic drive in

Ching-Ho Chang, Aida Flor A de la Cruz, Hung-Yu Lai, Isabel Mejia Natividad, Alex Noyola, Elian Angelo Magsino Abellanosa, Nicolas D Lee, Harmit S Malik

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ching-Ho ChangDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0001-9361-1190
Aida Flor A de la CruzDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Hung-Yu LaiInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Isabel Mejia NatividadDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Alex NoyolaDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0009-0006-5879-8950
Elian Angelo Magsino AbellanosaInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.ORCID 0000-0001-6352-8863
Nicolas D LeeDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0009-0008-9906-6363
Harmit S MalikDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0001-6005-0016

Funding

Resource Project CoreU41HG000739 · NHGRI · HARVARD UNIVERSITY · PI PERRIMON, NORBERT · 2014 to 2022
$32.3M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Genetic Conflict Shapes Centromeres and HeterochromatinR01GM074108 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MALIK, HARMIT S. · 2005 to 2022
$6.1M
NHGRI NIH HHS U41 HG000739NIGMS NIH HHS R01 GM074108NIH HHS P40 OD018537
6 · The paper itself

Abstract

Many animal species replace histones with protamines during spermatogenesis. Although essential for sperm function, protamines evolve rapidly for reasons that remain unknown. Using in vivo gene replacement, we examined the causes and consequences of the rapid evolution of

Indexed as

Drosophila melanogasterDrosophila ProteinsEvolution, MolecularMeiosisProtaminesAnimalsFemaleFertilityHistonesMaleSex RatioSpermatogenesisSpermatozoaX ChromosomeDrosophila ProteinsHistonesMst77F protein, DrosophilaProtamines

Identifiers

PMID42842684
PMCPMC13644785

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.