ArticleLife science alliance2026
Dysferlin promotes inflammatory macrophage responses and modulates Ca
Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Macrophage differentiation and activation shape tissue homeostasis and regeneration. Dysferlin (DYSF) is best known for its role in membrane repair in skeletal muscle, but its function in immune cells remains poorly understood. Here, we identify DYSF as a regulator of inflammatory macrophage-associated activation. DYSF expression increased during monocyte-to-macrophage differentiation. Gain- and loss-of-function analyses revealed that DYSF promoted inflammatory macrophage-associated responses, including cytokine production and migration. DYSF also enhanced Ca
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