ArticleNature communications2026
Arginine metabolism as a mutualistic strategy in the interaction between Porphyromonas gingivalis and Filifactor alocis.
Fangjie Zhou, Yajie Wu, Xian Peng, Yuqing Li, Wenyao Nie, Xiao Wang, Biao Ren, Jiyao Li
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Fangjie Zhou *State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yajie Wu *State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Xian PengState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yuqing LiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.ORCID 0000-0002-3410-6300 Wenyao NieState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Xiao WangState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Biao RenState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. renbiao@scu.edu.cn.ORCID 0000-0003-4215-2873 Jiyao LiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. jiyaoliscu@163.com.ORCID 0000-0002-2701-5179 Funding
National Natural Science Foundation of China (National Science Foundation of China) 32470205National Natural Science Foundation of China (National Science Foundation of China) 81991501National Natural Science Foundation of China (National Science Foundation of China) 82170949National Natural Science Foundation of China (National Science Foundation of China) 82401116Sichuan Provincial Department of Science and Technology | Sichuan Province Science and Technology Support Program 2023YFS0048
6 · The paper itselfAbstract
Metabolic cross-feeding is a main driver of microbial mutualism under various stresses. Elevated arginine levels in the periodontal microenvironment reshape pathogen physiology. Here, we discovered that increased arginine levels disrupted the intracellular amino acid metabolism of the periodontal pathogen Porphyromonas gingivalis by repressing glutamate dehydrogenase activity and α-ketoglutarate production via the accumulation of NH
Indexed as
ArginineEubacterialesPorphyromonas gingivalisSymbiosisAmmoniaBacterial ProteinsGene Expression Regulation, BacterialGlutamate DehydrogenaseHumansKetoglutaric AcidsPeriodontitisAmmoniaArginineBacterial ProteinsGlutamate DehydrogenaseKetoglutaric Acids
Identifiers
PMID42844246
PMCPMC13645793
What Socratic holds
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