Evidence map›Paper›PMID 42844247›Full record

ArticleSignal transduction and targeted therapy2026

Histone H4K5 lactylation-driven feedback loop modulates glycerol-linked immunosuppressive activity of tumor-associated T regulatory cells.

Wang Wang, Baida Kong, Changyuan Huang, Ke-Xu Xiong, Chuanxin Su, Yang Lu, Rongzhen Liang, Huimin Wang, Qi Long, Haoran Sun and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Wang Wang *Division of Oncology, Department of Medicine, Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Baida Kong *Central Laboratory, the People's Hospital of Chi Zhou and Chi Zhou Medical Academy of Research and Translation, Chi Zhou, Anhui, China.ORCID http://orcid.org/0000-0001-6912-0463
Changyuan Huang *The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, China.
Ke-Xu XiongShenzhen Key Laboratory of Viral Oncology, Clinical Innovation and Research Centre (CIRC), Shenzhen Hospital of Southern Medical University, Guangdong, China.
Chuanxin SuDeparment of Rheuamtology and Immunology, Peking University People's Hospital, Qingdao, Shandong, China.
Yang LuDepartment of Immunology, School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Rongzhen LiangDepartment of Immunology, School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huimin WangDepartment of Immunology, School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qi LongCentral Laboratory, the People's Hospital of Chi Zhou and Chi Zhou Medical Academy of Research and Translation, Chi Zhou, Anhui, China.
Haoran SunDepartment of Respiratory and Critical Care Medicine, the Second Affiliated Hospital, and Centre for Infection Immunity and Cancer (IIC) of Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Qi HuNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu, China.
Julie WangDivision of Oncology, Department of Medicine, Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chuanye ZhangDepartment of Immunology, School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wenxi HeHuadu Institute of Medical Sciences, Guangzhou, Huadu District People' s Hospital of Guangzhou, Guangzhou, China.
Linyu ShaDepartment of Immunology, School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yaping ZhiDepartment of Immunology, School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chi ZhouDepartment of Immunology, School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yiding XiongDepartment of Immunology, School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Li ZhouDivision of Oncology, Department of Medicine, Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xin ChenDepartment of Immunology, School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-7620-5975
Peng WangLiver Center, Ruijin Hospital, Jiao Tong University School of Medicine, Shanghai, China.
Bing-Hua JiangState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Department of Clinical Research and Translational Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lianhui SunDepartment of Immunology, School of Cell and Gene Therapy, Songjiang Research Institute and Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shimon SakaguchiLaboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan. shimon@ifrec.osaka-u.ac.jp.
Song Guo ZhengDivision of Oncology, Department of Medicine, Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China. song.zheng@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-5611-4774

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32400751National Natural Science Foundation of China (National Science Foundation of China) 82072902
6 · The paper itself

Abstract

Tumor metastasis is the leading cause of death for more than 90% of cancer patients, with colorectal cancer (CRC) mainly spreading to the liver. The colon and liver possess distinct nutritional microenvironments, yet how these differences shape the tumor immune landscape remains unclear. Using single-cell analysis of autologous samples from CRC patients with liver metastases, we identified a distinct CD177

Indexed as

Colorectal NeoplasmsGlycerolHistonesLiver NeoplasmsT-Lymphocytes, RegulatoryAnimalsFeedback, PhysiologicalForkhead Transcription FactorsHumansMiceTumor MicroenvironmentForkhead Transcription FactorsFOXP3 protein, humanGlycerolHistones

Identifiers

PMID42844247
PMCPMC13645786

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.