Evidence map›Paper›PMID 42844395›Full record

ArticleEuropean radiology2026

Quantitative ultrashort echo time (UTE) magnetic resonance imaging of femoral trabecular bone in aging and osteoporosis.

Jisook Yi, Arya Suprana, Yankai Meng, Yajun Ma, Eric Chang, Gina Woods, Charles Ginsberg, Saeed Jerban, Jiang Du

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Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jisook Yi *Department of Radiology, University of California San Diego, La Jolla, CA, USA.
Arya Suprana *Department of Radiology, University of California San Diego, La Jolla, CA, USA.
Yankai MengDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Yajun MaDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Eric ChangDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Gina WoodsDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Charles GinsbergDivision of Nephrology-Hypertension, University of California San Diego, San Diego, CA, USA.
Saeed JerbanDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Jiang DuDepartment of Radiology, University of California San Diego, La Jolla, CA, USA. jiangdu@health.ucsd.edu.ORCID http://orcid.org/0000-0002-9203-2450

Funding

Ultrashort Echo Time (UTE) Magnetic Resonance Imaging of BoneR01AR068987 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2015 to 2024
$4.9M
NINR NIH HHS R01AR068987
6 · The paper itself

Abstract

objectiveTo evaluate quantitative ultrashort echo time (UTE) magnetic resonance imaging (MRI) biomarkers, pore-to-matrix ratio (PMR), and matrix index (MI) for assessing trabecular bone in the proximal femur across aging and osteoporosis-related bone status. MATERIALS AND

methodsIn this prospective study, 92 female subjects (20-83 years) were classified into four groups based on age and DXA-derived T-scores: Young Normal (n = 19), Old Normal (n = 14), Osteopenia (n = 44), and Osteoporosis (n = 15). All participants underwent 3-T hip MRI using 3D dual-echo proton-density-weighted UTE (PD-UTE) and short TR adiabatic inversion recovery UTE (STAIR-UTE) sequences. Measurements were performed in the femoral head and neck by two readers. Interobserver agreement was assessed via intraclass correlation coefficients (ICC). Group differences were analyzed with the Kruskal-Wallis test and Holm-adjusted post hoc tests. Spearman correlation analysis and receiver operating characteristic (ROC) analysis were performed.

resultsPMR increased and MI decreased with worsening bone status. Significant differences were observed between Young Normal and all older groups (p < 0.001). PMR from the oblique-coronal total femoral head differentiated Old Normal from Osteoporosis (5.35 vs. 8.10; p < 0.05). Both PMR (ρ = -0.406 to -0.211) and MI (ρ = 0.333-0.402) significantly correlated with T-scores (all p < 0.05). The areas under the ROC curve were 0.776 (95% CI, 0.584-0.909) for PMR and 0.738 (95% CI, 0.548-0.886) for MI. Interobserver reproducibility was substantial to almost perfect (ICC: 0.73-0.99).

conclusionPMR and MI demonstrated measurable differences across age and bone status and may provide complementary information on trabecular bone characteristics. KEY POINTS: Question Can ultrashort echo time (UTE) MRI biomarkers address the need for radiation-free assessment of age- and osteoporosis-related trabecular bone changes in the proximal femur? Findings Pore-to-matrix ratio (PMR) increased and matrix index (MI) decreased with aging and worsening bone status, and femoral head PMR differentiated osteoporosis from normal bone. Clinical relevance UTE-MRI-derived PMR and MI may provide radiation-free, complementary information to dual-energy X-ray absorptiometry for assessing trabecular bone changes associated with aging and osteoporosis.

Indexed as

AgingFemurMagnetic resonance imagingOsteoporosis

Identifiers

PMID42844395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.