Evidence map›Paper›PMID 42844495›Full record

ArticleMolecular neurobiology2026

BMAL1 Overexpression in the SCN Confers Protection Against Anxiety-Like Behaviors of Chronic Sleep Restricted-Mice.

Xiao Li, Xiya Wang, Lanyue Gao, Jiayu Wang, Honghong Yu, Tingting Du, Tian Hu, Qi Sun

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiao Li *Shengjing Hospital of China Medical University, Heping District Shenyang, No.36 Sanhao Street, Liaoning, People's Republic of China.
Xiya Wang *Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education (China, Medical University), Shenyang, Liaoning, People's Republic of China.
Lanyue GaoKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education (China, Medical University), Shenyang, Liaoning, People's Republic of China.
Jiayu WangKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education (China, Medical University), Shenyang, Liaoning, People's Republic of China.
Honghong YuKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education (China, Medical University), Shenyang, Liaoning, People's Republic of China.
Tingting DuKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education (China, Medical University), Shenyang, Liaoning, People's Republic of China.
Tian HuKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education (China, Medical University), Shenyang, Liaoning, People's Republic of China.
Qi SunKey Laboratory of Environmental Stress and Chronic Disease Control & Prevention Ministry of Education (China, Medical University), Shenyang, Liaoning, People's Republic of China. sunqi@cmu.edu.cn.ORCID https://orcid.org/0000-0002-3648-0216

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children and adolescents globally experience inadequate sleep, which harms their cognitive functions and emotional regulation. The role of circadian clock genes in influencing the antioxidant and anti-inflammatory capabilities has been well-established. Previous studies reported that the impairment of neural activity within the suprachiasmatic nucleus (SCN) can lead to anxiety-like behaviors in mice. Our study was designed to explore the role of BMAL1 expression in SCN, which could be responsible for anxiety-like behaviors induced by chronic sleep restriction (SR) in young mice. Here, 5-week-old male mice were divided into four groups (CON

Indexed as

AnxietyARNTL Transcription FactorsBehavior, AnimalSleep DeprivationSuprachiasmatic NucleusAnimalsMaleMiceMice, Inbred C57BLNeuronal PlasticityPrefrontal CortexARNTL Transcription FactorsBmal1 protein, mouseAnxiety-like behaviorsBMAL1InflammationSleep restrictionSynaptic plasticity

Identifiers

PMID42844495

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.