ArticleFrontiers in bioengineering and biotechnology2026
Graphene oxide-engineered dental implants: orchestrating antibacterial defense and osteo-immunomodulation for enhanced osseointegration.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dental implant technology has brought significant benefits to millions of patients with missing teeth, substantially improving their quality of life. However, titanium-based dental implants still face two stubborn problems-peri-implant infection and inadequate osseointegration, which seriously undermine their therapeutic outcomes and overall clinical success. To address these two key bottlenecks, this study developed a graphene oxide (Graphene oxide)-engineered dental implant endowed with synergistic antibacterial and osteoimmunomodulatory properties. This implant exhibited broad-spectrum antibacterial effects against three common pathogenic strains in dentistry by disrupting bacterial cell membranes and increasing intracellular reactive oxygen species (ROS) levels. Moreover, the implant regulated the macrophage polarization toward a pro-regenerative phenotype, thereby optimizing the local immune microenvironment and promoting the extension and differentiation of osteoblasts.
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