Evidence map›Paper›PMID 42846136›Full record

ReviewFood science & nutrition2026

Efficacy of Vitamin E Administration on Serum Lipid Profile in Adult Patients With Dyslipidemia: A GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis of RCTs.

Mehdi Karimi, Kimia Kazemi, Fatemeh Ziyafati, Fereshteh Valizadeh, Niyousha Shirsalimi, Sepehr Ramezanipour, Ali Estifa, Omid Asbaghi

Abstract readReview
In one paragraph

Review in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mehdi KarimiFaculty of Medicine Bogomolets National Medical University (NMU) Kyiv Ukraine.ORCID https://orcid.org/0009-0006-4388-0214
Kimia KazemiDepartment of Food Science and Technology Islamic Azad University-Ayatollah Amoli Branch Amol Iran.ORCID https://orcid.org/0009-0000-0777-7646
Fatemeh ZiyafatiDepartment of Genetics, Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine, ACECR Tehran Iran.ORCID https://orcid.org/0009-0002-8135-8620
Fereshteh ValizadehFaculty of Medicine Shahid Beheshti University of Medical Sciences (SBUMS) Tehran Iran.ORCID https://orcid.org/0000-0002-1609-9493
Niyousha ShirsalimiFaculty of Medicine Hamadan University of Medical Sciences (UMSHA) Hamadan Iran.ORCID https://orcid.org/0000-0002-3337-942X
Sepehr RamezanipourStudent Research Committee Fasa University of Medical Sciences Fasa Iran.ORCID https://orcid.org/0009-0007-4735-0859
Ali EstifaDepartment of Sport Sciences Imam Khomeini International University Qazvin Iran.ORCID https://orcid.org/0000-0002-8035-6044
Omid AsbaghiCancer Research Center Shahid Beheshti University of Medical Sciences (SBUMS) Tehran Iran.ORCID https://orcid.org/0000-0002-7740-4711

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dyslipidemia is a major risk factor for cardiovascular disease. Studies have shown that vitamin E has therapeutic effects on lipid metabolism; however, findings remain inconsistent. This meta-analysis aims to assess the effectiveness of vitamin E administration on the serum lipid panel in patients with dyslipidemia. A database search through January 2026 was conducted to identify relevant randomized controlled trials (RCTs). Relevant data, including triglycerides (TG), total cholesterol (TC), and low- and high-density lipoprotein cholesterol (LDL-C and HDL-C), were extracted. The overall effect size was estimated using weighted mean differences (WMDs) with 95% confidence intervals (CIs) via a random-effects model. The pooled analysis of 22 RCTs (33 intervention arms) demonstrated that vitamin E significantly lowered TG (WMD: -8.14 mg/dL,

Indexed as

blood lipidscardiovascular diseasedyslipidemiahyperlipidemianutritional supplementationtocopheroltocotrienolvitamin E

Identifiers

PMID42846136
PMCPMC13643374

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.