Evidence map›Paper›PMID 42846753›Full record

ArticleFood science & nutrition2026

Enzyme-Digested Edible Bird's Nest Promotes NGF-Induced Differentiation of PC12 Cells by Activating the TrkA-ERK1/2-CREB-BDNF Signaling Pathway.

Wen Zhang, Xintong Wang, Huiqing Zhu, Xiaoxian Lin, Rongzi Li, Man Yuan, Baocai Xu, Dongliang Wang, Wei Xiong, Yixuan Li

Abstract read
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In one paragraph

Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wen ZhangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Xintong WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Huiqing ZhuKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Xiaoxian LinHebei Edible Bird's Nest Fresh Stew Technology Innovation Center Langfang Hebei China.
Rongzi LiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.
Man YuanHebei Edible Bird's Nest Fresh Stew Technology Innovation Center Langfang Hebei China.
Baocai XuSchool of Food and Biological Engineering Hefei University of Technology Hefei Anhui China.ORCID https://orcid.org/0000-0002-0706-8863
Dongliang WangHebei Edible Bird's Nest Fresh Stew Technology Innovation Center Langfang Hebei China.ORCID https://orcid.org/0000-0001-9272-8071
Wei XiongFood Laboratory of Zhongyuan Luohe Henan China.
Yixuan LiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health China Agricultural University Beijing China.ORCID https://orcid.org/0000-0002-8000-3417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuroprotective properties of edible bird's nest (EBN) are well established; however, its effects on neuronal growth remain unclear. In this study, we investigated the effects of enzyme-digested EBN (EBND) on neurogenesis in the PC12 neuronal cell line. Although treatment with EBND alone did not significantly promote the differentiation of PC12 cells, it increased neurite outgrowth and neurofilament expression when co-administered with nerve growth factor (NGF). Moreover, EBND significantly augmented the NGF-induced phosphorylation of TrkA and ERK1/2, which in turn activated CREB and increased brain-derived neurotrophic factor (BDNF) expression. Notably, these effects of EBND were diminished by the TrkA inhibitor GW441756. Taken together, these findings suggest that combined treatment with EBND and NGF enhances neurogenesis in PC12 cells by activating the TrkA-ERK-CREB-BDNF signaling pathway.

Indexed as

edible bird's nestneuronal differentiationPC12 cellsTrkA‐ERK1/2‐CREB‐BDNF

Identifiers

PMID42846753
PMCPMC13643363

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.