ArticleFrontiers in veterinary science2026
Neuroimmune responses in the chicken brain during acute fowl adenovirus serotype 4 infection.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Introduction: Fowl adenovirus serotype 4 (FAdV-4) causes fatal hepatitis in chickens and has a substantial impact on the poultry industry. The virus primarily targets the liver in chickens. Although viral load in the brain has been previously reported, the association of acute FAdV-4 infection with brain immune response remains poorly characterized. Therefore, this study focuses on immune alterations in the brain during acute FAdV-4 infection. Methods: Here, we investigated an increase in immune cell populations, along with the expression of barrier-related genes, to define the neuroimmune response during FAdV-4 infection. Results: Our results demonstrated that there was an alteration in the immune cell population, characterized by an increased frequencies of activated monocytes/macrophages and T cell subsets in the brain from infected chickens. Additionally, the CD44 Discussion: Together, these findings suggest acute FAdV-4 infection-associated neuroimmune alterations, mapping a distinct immunophenotypic and transcriptional landscape within the avian brain.
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