Evidence map›Paper›PMID 42847323›Full record

ArticleEuropean journal of immunology2026

Integrated Metabolomic and Bioenergetic Profiling Reveals Axl as a Key Regulator of Macrophage Homeostasis.

Jesuino R M Ferreira, Thais S Rigoni, Monique S Leandro, Kamila Guimarães-Pinto, Letícia R Ramos, André L A Costa, Clara F Carvalho, Caroline F Martiniuc, Isadora A Oliveira, Carolina Maia and 6 more

Abstract read
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In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jesuino R M FerreiraLaboratório de Imunologia Celular, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Thais S RigoniPlataforma Bi-Institucional de Pesquisa em Medicina Translacional FIOCRUZ SP/Faculdade de medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Monique S LeandroLaboratório de Imunologia Celular, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Kamila Guimarães-PintoLaboratório de Imunologia Celular, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Letícia R RamosLaboratório de Imunologia Celular, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
André L A CostaLaboratório de Imunologia Celular, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Clara F CarvalhoLaboratório de Bioenergética e Fisiologia Mitocondrial, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Caroline F MartiniucLaboratório de Biotecnologia e Ecologia Microbiana, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Isadora A OliveiraCentro de Espectrometria de Massas de Biomoléculas (CEMBIO), Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Carolina MaiaLaboratório de Imunologia Celular, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Júlia MoratelliLaboratório de Imunologia Celular, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Jefferson A LeiteLaboratório de Biologia de Linfócitos T, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Verônica S PintoLaboratório de Bioquímica do Exercício e Motores Moleculares, Escola de Educação Física e Desportos (EEFD), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Adriane TodeschiniLaboratório de Glicobiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Antônio GalinaLaboratório de Bioenergética e Fisiologia Mitocondrial, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Alessandra A FilardyLaboratório de Imunologia Celular, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Funding

Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES Foundation) 001Brazilian National Council for Scientific and Technological Development (CNPq)Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ)
6 · The paper itself

Abstract

The TAM receptor Axl is essential for efferocytosis and inflammatory regulation, but its role in macrophage immunometabolic homeostasis remains unclear. Here, we combined phenotypic, functional, metabolomic, and bioenergetic analyses to define how Axl deficiency alters peritoneal macrophages (PMs) under steady-state conditions. Axl

Indexed as

Energy MetabolismHomeostasisMacrophagesMacrophages, PeritonealProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesAnimalsAxl Receptor Tyrosine KinaseEfferocytosisGlycolysisMetabolomicsMiceMice, Inbred C57BLMice, KnockoutMitochondriaOxidative StressAxl Receptor Tyrosine KinaseAXL receptor tyrosine kinase, mouseProto-Oncogene ProteinsReactive Oxygen SpeciesReceptor Protein-Tyrosine KinasesAxl receptorimmunometabolismoxidative stressperitoneal macrophages

Identifiers

PMID42847323

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.