Evidence map›Paper›PMID 42848175›Full record

ReviewProbiotics and antimicrobial proteins2026

Faecalibacterium prausnitzii: Mechanistic Insights and Therapeutic Potential in Host-Microbe Crosstalk.

Wenfei Qin, Guangqiang Wang, Yang Fu, Yue Zeng, Yongjun Xia, Yi Sheng, Lianzhong Ai

Abstract readReview
PubMed Publisher
In one paragraph

Review in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenfei Qin *School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 201100, China.
Guangqiang Wang *School of Health Science and Engineering, Shanghai Engineering Research Center of Food Microbiology, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Yang FuDepartment of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Yue ZengDepartment of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Yongjun XiaSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 201100, China.
Yi ShengSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 201100, China.
Lianzhong AiSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 201100, China. ailianzhong1@126.com.

Funding

National Natural Science Foundation of China No. U23A20261Shanghai Agriculture Applied Technology Development Program, China No. 2024-02-08-00-12-F00040Shanghai Engineering Research Center of Food Microbiology No.19DZ2281100Shanghai Key Technology R&D Program 'Synthetic Biology' Project 25HC2830500
6 · The paper itself

Abstract

Faecalibacterium prausnitzii (Fp), a potential candidate for a next-generation, is widely distributed in the feces and intestinal tract of mammals. Accumulating evidence indicates that Fp and its metabolites exert anti-inflammatory, immunomodulatory, and maintain intestinal barrier integrity. In this review, we summarize the biological characteristics of Fp and its nutritional cross feeding interactions with other microbial species. We further synthesize current evidence on the local roles of Fp in intestinal diseases and systemic effects on distant organs via the gut-organ axis. Furthermore, we outline the mechanisms by which its effector molecules, including butyrate, microbial anti-inflammatory molecule (MAM), and extracellular vesicles (EVs), contribute to disease amelioration. Finally, we discuss the current challenges and future perspectives for Fp. Collectively, as an important commensal bacterium in the gut, Fp provides a theoretical basis for the development of novel functional microorganisms with probiotic properties.

Indexed as

Bioactive metabolitesBiological characteristicsFaecalibacterium prausnitziiGut-organ axisHost homeostasis

Identifiers

PMID42848175

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.