Evidence map›Paper›PMID 42848243›Full record

ArticleNeurochemical research2026

Maresin1 Improves Angiogenesis and Cognitive Function by Regulating Perivascular Macrophages in Rats with Chronic Cerebral Hypoperfusion.

Hao Song, Miaoyu Du, Haoying He, Ran Zhang, Fan Fan, Shuhan Xie, Jin Zhang, Tian Li, Changhua Qu, Junjian Zhang

Abstract read
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In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hao Song *Department of Neurology, Hubei Provincial Clinical Research Center for Dementia and Cognitive Impairment, Zhongnan Hospital of Wuhan University, No.169 Donghu Street, Wuhan, 430000, Hubei, China.
Miaoyu Du *Department of Neurology, Hubei Provincial Clinical Research Center for Dementia and Cognitive Impairment, Zhongnan Hospital of Wuhan University, No.169 Donghu Street, Wuhan, 430000, Hubei, China.
Haoying He *Department of Neurology, Hubei Provincial Clinical Research Center for Dementia and Cognitive Impairment, Zhongnan Hospital of Wuhan University, No.169 Donghu Street, Wuhan, 430000, Hubei, China.
Ran ZhangDepartment of Neurology, Hubei Provincial Clinical Research Center for Dementia and Cognitive Impairment, Zhongnan Hospital of Wuhan University, No.169 Donghu Street, Wuhan, 430000, Hubei, China.
Fan FanDepartment of Neurology, Huanggang Central Hospital, Huanggang, 438000, Hubei, China.
Shuhan XieDepartment of Neurology, Hubei Provincial Clinical Research Center for Dementia and Cognitive Impairment, Zhongnan Hospital of Wuhan University, No.169 Donghu Street, Wuhan, 430000, Hubei, China.
Jin ZhangDepartment of Neurology, Hubei Provincial Clinical Research Center for Dementia and Cognitive Impairment, Zhongnan Hospital of Wuhan University, No.169 Donghu Street, Wuhan, 430000, Hubei, China.
Tian LiDepartment of Neurology, Hubei Provincial Clinical Research Center for Dementia and Cognitive Impairment, Zhongnan Hospital of Wuhan University, No.169 Donghu Street, Wuhan, 430000, Hubei, China. litian@whu.edu.cn.
Changhua QuDepartment of Neurology, Minda Hospital of Hubei Minzu University, No. 2 Wufengshan Road, Enshi, 445000, Hubei, China. 546473062@qq.com.
Junjian ZhangDepartment of Neurology, Hubei Provincial Clinical Research Center for Dementia and Cognitive Impairment, Zhongnan Hospital of Wuhan University, No.169 Donghu Street, Wuhan, 430000, Hubei, China. zhangjj@whu.edu.cn.ORCID https://orcid.org/0000-0002-4557-5137

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 82071210National Key Research and Development Program of China 2021YFC2500102the Enshi Innovation and Development Joint Fund Project 2025AFD143the Hubei Provincial Clinical Research Center for Dementia and Cognitive Impairment PTYX2024024the Zhongnan Hospital of Wuhan University Medical Science and Technology Innovation Platform Support Project PTXM2020006
6 · The paper itself

Abstract

Population aging imposes a substantial dementia burden. Chronic cerebral hypoperfusion (CCH) serves as a crucial early pathological basis for Alzheimer's disease (AD) and Vascular Dementia (VaD). Our previous studies have demonstrated that macrophage-derived docosahexaenoic acid metabolite Maresin1 can ameliorate CCH-induced cognitive impairment, though the underlying angiogenesis-related mechanisms remain to be elucidated. We developed a rat model of chronic cerebral hypoperfusion using the bilateral common carotid artery occlusion surgical approach. Cognitive improvements and angiogenic mechanisms by Maresin1 were systematically evaluated using behavioral assessments, immunofluorescence techniques, Western blotting (WB), ELISA, and cerebral blood flow measurements via laser Doppler. Our findings revealed that Maresin1 administration significantly ameliorated CCH-induced cognitive deficits, promoted hippocampal angiogenesis and enhanced cerebral perfusion. Further analysis showed significant enhancement of IGF-1/p-Akt/VEGF/eNOS signaling pathway activation by Maresin1, and the increased VEGF expression was predominantly mediated by perivascular macrophage (pvMΦ) activation. Depletion of pvMΦ using clodronate liposomes suppressed the VEGF upregulation and cognitive improvement mediated by Maresin1. Our research demonstrates that IGF-1/p-Akt/VEGF pathway activation in pvMΦ plays a crucial role in Maresin1-mediated angiogenesis in CCH rats.

Indexed as

AngiogenesisBrain IschemiaCognitionDocosahexaenoic AcidsMacrophagesAnimalsCerebrovascular CirculationMaleRatsRats, Sprague-DawleySignal TransductionSpecialized Pro-Resolving Mediators7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acidDocosahexaenoic AcidsAngiogenesisChronic cerebral hypoperfusionCognitive impairmentMaresin1Perivascular macrophage

Identifiers

PMID42848243

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.