ArticleEuropean journal of epidemiology2026
Omega-3 cord plasma proportions and cognitive function trajectories from 5 to 15 years of age: a population-based cohort study.
Article in European journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal diet during pregnancy, particularly omega-3 fatty acids, is critical for neurodevelopment, yet long-term associations with cognitive trajectories remain unclear. We evaluated prenatal omega-3 exposure in relation to longitudinal trajectories of inattentiveness, working memory, and fluid intelligence from childhood through adolescence within the Spanish Environment and Childhood project. Cord plasma proportions of alfa‑linolenic acid (ALA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) were measured in 953 participants. Linear mixed-effects models evaluated overall average main effects and age-interaction cognitive trajectories across follow-up (5-15 years). In main effect models, higher ALA and DHA proportions were associated with lower overall inattentiveness (β = - 0.19, 95% CI: - 0.35, - 0.02; and β = - 0.20, 95% CI: - 0.35, - 0.04, respectively), and higher DHA was associated with better overall working memory (β = 0.24, 95% CI: 0.08, 0.39). Longitudinal interaction models with age revealed domain-specific trajectories. Higher cord plasma ALA was associated with early advantages in attention and fluid intelligence, but exhibited significant attenuation over time (β = 0.10, 95%CI = 0.06; 0.14; and β = - 0.11, 95%CI = - 0.15; - 0.07). Conversely, higher DHA predicted steeper trajectory improvements over time for inattentiveness (β = - 0.06, 95%CI = - 0.10; - 0.02) and fluid intelligence (β = 0.08, 95%CI = 0.04; 0.12), alongside marked early childhood advantages in working memory that attenuated over time (β = - 0.05, 95%CI = - 0.09; - 0.01). Prenatal omega‑3 s may show distinct domain-specific and age-dependent associations with cognitive trajectories. Cord plasma ALA may support early attention and fluid intelligence, whereas DHA may contribute to sustained long-term cognitive maturation alongside early working memory performance.
Indexed as
Identifiers
42848266What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.