Evidence map›Paper›PMID 42850259›Full record

ArticleNature communications2026

Role of PER-WDR5 interactions in the mammalian circadian clock.

Arne Börgel, Florian Hof, Mareen Welzel, Audrey Rawleigh, Marcel Wedemann, Rafaela Mororo Cavalcanti Keller, Vanessa Maissl, Kyra Ricci, Sandra Schick, Helen L May-Simera and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Arne Börgel *Institute of Molecular Physiology (IMP), Johannes Gutenberg-University Mainz, Mainz, Germany.
Florian Hof *Institute of Molecular Physiology (IMP), Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0002-6438-1784
Mareen WelzelIntegrative Systems Biology Group, Institute of Molecular Biology (IMB), Mainz, Germany.
Audrey RawleighChronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
Marcel WedemannInstitute of Molecular Physiology (IMP), Johannes Gutenberg-University Mainz, Mainz, Germany.
Rafaela Mororo Cavalcanti KellerLaboratory of Chronobiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Vanessa MaisslInstitute of Molecular Physiology (IMP), Johannes Gutenberg-University Mainz, Mainz, Germany.
Kyra RicciChronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
Sandra SchickChromatin Regulation Group, Institute of Molecular Biology (IMB), Mainz, Germany.
Helen L May-SimeraInstitute of Molecular Physiology (IMP), Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0002-9477-4036
Steven BrownChronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
Achim KramerLaboratory of Chronobiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-9671-6078
Katja LuckIntegrative Systems Biology Group, Institute of Molecular Biology (IMB), Mainz, Germany.ORCID http://orcid.org/0000-0003-2336-9225
Jürgen A RippergerDepartment of Biology, University of Fribourg, Fribourg, Switzerland. juergenalexandereduard.ripperger@unifr.ch.ORCID http://orcid.org/0000-0002-9345-5172
Eva WolfInstitute of Molecular Physiology (IMP), Johannes Gutenberg-University Mainz, Mainz, Germany. evawolf1@uni-mainz.de.ORCID http://orcid.org/0000-0003-1345-6114

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) Emmy Noether project-ID 449991970Deutsche Forschungsgemeinschaft (German Research Foundation) GRK2526/1/2-Project-ID 407023052Deutsche Forschungsgemeinschaft (German Research Foundation) SFB 1361-Project-ID 393547839Deutsche Forschungsgemeinschaft (German Research Foundation) SFB1551 project-ID 464588647
6 · The paper itself

Abstract

In the mammalian circadian clock, the transcription factor CLOCK/BMAL1 cycles between an active state recruiting co-activators like MLL1 and repressed states associated with PER1/2 and CRY1/2 clock proteins. The MLL1 complex component WDR5 was also found in a repressive PER complex. Here we show that WDR5 directly binds to the CRY binding domain (CBD) regions of PER1 and PER2. PER2 binds WDR5 via a WBM motif within the PER2/CRY interface, imposing competition between PER2/WDR5-, PER2/CRY- and RbBP5/WDR5 complexes. PER1 binds WDR5 predominantly via a WIN motif outside the CBD, enabling formation of trimeric PER1

Indexed as

Circadian ClocksHistone-Lysine N-MethyltransferaseIntracellular Signaling Peptides and ProteinsPeriod Circadian ProteinsAnimalsARNTL Transcription FactorsCryptochromesHEK293 CellsHumansMiceProtein BindingARNTL Transcription FactorsCryptochromesHistone-Lysine N-MethyltransferaseIntracellular Signaling Peptides and ProteinsPER2 protein, humanPeriod Circadian ProteinsWDR5 protein, human

Identifiers

PMID42850259

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.