Generation of a novel knock-in mouse line expressing oncogenic Kit D814V in the hematopoietic stem cell compartment as a preclinical model for systemic mastocytosis.

Simona Stivala, Alina Makeeva, Tiago Almeida Fonseca, Elena Ratti, Etnik Sheremeti, Laetitia Clauss, Marc Usart, Ewelina M Bartoszek, Pawel Pelczar, Martina Konantz and 1 more

Abstract read

PubMed Publisher

In one paragraph

Article in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Simona StivalaDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-1549-8932

Alina MakeevaDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-0090-5902

Tiago Almeida FonsecaDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.

Elena RattiDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.

Etnik SheremetiDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.

Laetitia ClaussDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID http://orcid.org/0009-0004-8464-6120

Marc UsartDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.

Ewelina M BartoszekDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0001-5153-9258

Pawel PelczarCenter for Transgenic Models, University of Basel, Basel, Switzerland.

Martina KonantzDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-4319-3119

Karin HartmannDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland. karin.hartmann@usb.ch.ORCID http://orcid.org/0000-0002-4595-8226

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_207705

6 · The paper itself

Abstract

Research in mastocytosis, characterized by clonal expansion of mast cells (MC), and driven by the KIT D816V mutation in >90% of patients, has been hampered by the lack of in vivo models. Here, we describe a novel knock-in mouse line expressing Kit D814V (murine homolog to human KIT D816V) in the hematopoietic compartment by Scl-CreER-mediated recombination. Scl-Cre;Kit

Identifiers

PMID42850348

DOI10.1016/j.jaci.2012.11.008

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.