Evidence map›Paper›PMID 42850351›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Modulation of the noradrenergic system using transcranial ultrasonic stimulation targeted to the brainstem locus coeruleus in awake mice.

Emma Lescrauwaet, Robrecht Raedt, Tom Plovie, Sielke Caestecker, Bethany Stieve, Sara Neyt, Thomas Tarnaud, Emmeric Tanghe, Keith Murphy, Evelien Carrette and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emma Lescrauwaet4BRAIN, Department of Neurology, Ghent University Hospital, Ghent, Belgium. Emma.lescrauwaet@ugent.be.
Robrecht Raedt4BRAIN, Department of Neurology, Ghent University Hospital, Ghent, Belgium.
Tom PlovieINTEC WAVES - IMEC, Department of Information Technology, Ghent University, Ghent, Belgium.
Sielke Caestecker4BRAIN, Department of Neurology, Ghent University Hospital, Ghent, Belgium.
Bethany Stieve4BRAIN, Department of Neurology, Ghent University Hospital, Ghent, Belgium.
Sara NeytiBME-MEDISIP-Infinity Lab, Department of Electronics and Information Systems, Ghent University, Ghent, Belgium.
Thomas Tarnaud4BRAIN, Department of Neurology, Ghent University Hospital, Ghent, Belgium.ORCID http://orcid.org/0000-0001-7280-4348
Emmeric TangheINTEC WAVES - IMEC, Department of Information Technology, Ghent University, Ghent, Belgium.
Keith MurphyDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Evelien Carrette4BRAIN, Department of Neurology, Ghent University Hospital, Ghent, Belgium.
Paul Boon4BRAIN, Department of Neurology, Ghent University Hospital, Ghent, Belgium.
Kristl Vonck4BRAIN, Department of Neurology, Ghent University Hospital, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial ultrasound stimulation (TUS) is a novel neuromodulation technique that can be used to non-invasively target the locus coeruleus (LC). The LC provides the majority of noradrenergic input to the brain and has been implicated in several neurological and psychiatric disorders. Before translation to human studies, establishing a dose-response relationship requires systematic characterization of two distinct effects: (1) the influence of stimulation protocol variations on norepinephrine (NE) release in LC target structures, and (2) the broader brain and bodily effects of LC-targeted TUS. We used fiber photometry to measure TUS-induced activation of LC neurons and release of NE in one of its major projection areas, the hippocampus. To evaluate widespread functional effects, we investigated changes in [

Identifiers

PMID42850351

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.