ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2026
Insulin resistance is potentially associated with 24-h blood pressure variability related to blunted sympathetic reactivity in older adults with hypertension.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purposeBlood pressure variability (BPV) increases with aging and hypertension; however, the underlying mechanisms remain poorly understood. Aging-related insulin resistance is known to contribute to abnormalities in autonomic circulatory regulation. Although hypertension and autonomic dysfunction are closely linked, it remains unclear whether hypertension modifies the effects of insulin resistance on autonomic cardiovascular control and BPV. Since daily life is mostly spent upright, sympathetic responses to postural change may determine BPV. Therefore, we aimed to determine whether insulin resistance is associated with muscle sympathetic nerve activity (MSNA) responses to orthostatic stress in older adults with and without hypertension.
methodsWe studied 37 older adults without hypertension (normotension [NTN]) and 30 older patients with hypertension (HTN) without diabetes mellitus. Participants underwent 30° and 60° head-up tilt (HUT), whereby MSNA responses were assessed. In addition to 24-h BPV, fasting glucose, insulin, and homeostasis-model-assessment-estimated insulin resistance (HOMA-IR) were measured.
resultsHTN exhibited higher 24-h BPV. There were no significant group differences in MSNA responses to HUT or in fasting glucose, insulin, or HOMA-IR. Importantly, however, only in the HTN group, MSNA responses to HUT were negatively correlated with fasting glucose and HOMA-IR. In multivariable models adjusting for age, sex, and body mass index (BMI), fasting glucose remained an independent predictor of MSNA responsiveness. Furthermore, mediation analysis revealed indirect associations of fasting glucose and HOMA-IR with 24-h BPV in relation to attenuated MSNA responses to HUT.
conclusionsIn older adults with hypertension, insulin resistance may be associated with elevated BPV through blunted sympathetic responses to orthostatic stress.
Indexed as
Identifiers
42850365What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.