ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
MIND diet-related plasma proteins are associated with Alzheimer's disease risk.
Shane Fernandez, Desarae A Dempsey, Soumilee Chaudhuri, Yen-Ning Huang, Tamina Park, Shiwei Liu, Frederick W Unverzagt, Sujuan Gao, Global Neurodegeneration Proteomics Consortium, Donna M Wilcock and 5 more
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In one paragraphArticle in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
15 authors.
Soumilee ChaudhuriCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Yen-Ning HuangCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Tamina ParkCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Shiwei LiuCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Frederick W UnverzagtIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sujuan GaoIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Global Neurodegeneration Proteomics Consortium
Donna M WilcockStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jiaqi YangDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Casey M RebholzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Funding
Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MONICA G. RIVERA-MINDT · 2016 to 2026
$226.7MARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7MPeripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Minerva Maria Carrasquillo, NILUFER ERTEKIN-TANER · 2023 to 2026
$42.0MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MResearch Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1MUltrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7MTHE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7MARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9MKBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems BiologyU01AG072177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LEE, DONG YOUNG, NHO, KWANGSIK TIMOTHY · 2021 to 2025
$11.2MARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5MARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4MMemory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9MNational Heart, Lung, and Blood Institute (NHLBI), NIH R01 HL153178National Institute on Aging (NIA)National Institutes of Health (NIH): P30AG010133National Institutes of Health (NIH): P30AG072976National Institutes of Health (NIH): R01AG019771National Institutes of Health (NIH): R01AG057739National Institutes of Health (NIH): R01AG068193National Institutes of Health (NIH): R01LM012535National Institutes of Health (NIH): T32AG071444National Institutes of Health (NIH): U01AG068057National Institutes of Health (NIH): U01AG072177National Institutes of Health (NIH): U19AG024904National Institutes of Health (NIH): U19AG074879National Library of Medicine (NLM) NIH R01LM012535National Library of Medicine (NLM) NIH R01 LM013463NHLBI, NIH, Department of Health and Human Services 75N92022D00001NHLBI, NIH, Department of Health and Human Services 75N92022D00002NHLBI, NIH, Department of Health and Human Services 75N92022D0000375N92022D00004NHLBI, NIH, Department of Health and Human Services 75N92022D00005NIH (NHLBI, NINDS, NIA and NIDCD) U01HL096812NIH (NHLBI, NINDS, NIA and NIDCD) U01HL096814NIH (NHLBI, NINDS, NIA and NIDCD) U01HL096899NIH (NHLBI, NINDS, NIA and NIDCD) U01HL096902NIH (NHLBI, NINDS, NIA and NIDCD) U01HL096917
6 · The paper itselfAbstract
introductionAdherence to the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet is associated with reduced dementia risk, but underlying mechanisms remain unclear.
methodsPlasma proteomics (SomaScan 7k) from 206 Indiana Alzheimer's Disease Research Center participants were analyzed using network analysis to identify modules associated with MIND diet scores. Diet-related hub proteins were then investigated for associations with Alzheimer's disease (AD) phenotypes and as potential diet-AD outcome mediators. Validation analyses were conducted in the Atherosclerosis Risk in Communities study (n = 10,228) and Global Neurodegeneration Proteomics Consortium (n = 3,723) datasets.
resultsHigher MIND diet scores were associated with lower AD odds (odds ratio = 0.75, p = 0.01) and lower plasma neurofilament light chain levels (β = -0.07, p = 0.02). Two proteins, MCTS1 and cytidylate kinase, were associated with MIND diet and AD risk, and may mediate their relationship (p[a × b < 0] ≥ 0.95). Validation analyses supported the MCTS1 finding. DISCUSSION: Vascular-related biological mechanisms may underlie associations between diet and dementia risk.
Indexed as
Alzheimer DiseaseBlood ProteinsDietary Approaches To Stop HypertensionDiet, MediterraneanAgedFemaleHumansMaleProteomicsRisk FactorsBlood ProteinsAlzheimer's diseasedementia riskexposomeMediterranean–Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay dietplasma proteomics
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