ArticleFrontiers in cellular and infection microbiology2026
Epidemiology and lagged climatic drivers of pediatric viral lower respiratory tract infections in Tianjin, China (2023-2025).
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Following the lifting of pandemic-era restrictions, China experienced a sharp resurgence in pediatric respiratory infections; however, post-pandemic epidemiological and climatic data on lower respiratory tract infections (LRTIs) from the temperate continental climate of northern China remain scarce. Methods: In this retrospective, single-center surveillance study, we characterized the post-pandemic epidemiology of six respiratory viruses in children hospitalized with LRTI in Tianjin and assessed their pathogen-specific, lagged climatic associations. Children aged 0-18 years hospitalized between January 2023 and December 2025 were tested by targeted next-generation sequencing for human rhinovirus (HRV), adenovirus (ADV), respiratory syncytial virus (RSV), human bocavirus (HBoV), influenza virus (IFV), and human metapneumovirus (HMPV). Pathogen-climate associations were estimated using a quasi-Poisson model that adjusted for seasonality, secular trend, and lagged meteorological exposures. Results: Among 2,597 virus-positive cases, the leading pathogens were HRV (30.7%), ADV (26.6%), and RSV (20.6%), followed by HBoV (12.1%), IFV (6.0%), and HMPV (4.0%). Age distributions differed by pathogen (p<0.05): RSV and HBoV predominated in infants and toddlers, HRV and HMPV in preschoolers, ADV in school-aged children, and IFV across the older preschool-to-school-age range; males predominated for all viruses except IFV. Five viruses peaked in December, whereas HBoV peaked uniquely in July. After adjustment for seasonality and secular trend, the unadjusted associations of IFV with humidity and temperature disappeared, indicating that they largely reflected shared seasonality. In contrast, RSV retained associations with temperature (RR 3.87, 95% CI 1.39-10.76) and wind speed (RR 5.46, 95% CI 2.39-12.47) at a 1-month lag, and HMPV with temperature (RR 13.3, 95% CI 1.64-108.3; imprecise given its low case count); HRV, ADV, and HBoV showed no independent climatic associations. Co-infections occurred in 116 cases (4.5%), most frequently HBoV+HRV (23.3%). Conclusion: Post-pandemic pediatric viral LRTI in Tianjin shows distinctive pathogen-specific profiles in age, seasonality, and climatic sensitivity. The summer peak of HBoV and the seasonally independent climatic drivers of RSV and HMPV provide a preliminary basis that, if confirmed with higher-resolution data, could inform pathogen-tailored, climate-informed surveillance in northern Chinese megacities.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.