Evidence map›Paper›PMID 42852091›Full record

ArticleChemical science2026

PNA-ligand conjugates enable site-selective and directional targeting of adjacent G-quadruplexes.

Raffaele Graziano, Enrico Cadoni, Simona Marzano, Valentina Arciuolo, Naura Fakhira Antariksa, Marco Di Antonio, Jussara Amato, Annemieke Madder, Bruno Pagano

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Raffaele GrazianoDepartment of Pharmacy, University of Naples Federico II Via D. Montesano 49 80131 Naples Italy bruno.pagano@unina.it.
Enrico CadoniOrganic and Biomimetic Chemistry Research Group, Department of Organic and Macromolecular Chemistry, Ghent University Krijgslaan 281-S4 9000 Ghent Belgium annemieke.madder@ugent.be.ORCID https://orcid.org/0000-0001-5585-7579
Simona MarzanoDepartment of Pharmacy, University of Naples Federico II Via D. Montesano 49 80131 Naples Italy bruno.pagano@unina.it.
Valentina ArciuoloDepartment of Pharmacy, University of Naples Federico II Via D. Montesano 49 80131 Naples Italy bruno.pagano@unina.it.ORCID https://orcid.org/0009-0008-8001-8898
Naura Fakhira AntariksaDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London 82 Wood Lane London W12 0BZ UK.
Marco Di AntonioDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London 82 Wood Lane London W12 0BZ UK.ORCID https://orcid.org/0000-0002-7321-1867
Jussara AmatoDepartment of Pharmacy, University of Naples Federico II Via D. Montesano 49 80131 Naples Italy bruno.pagano@unina.it.ORCID https://orcid.org/0000-0001-6096-3544
Annemieke MadderOrganic and Biomimetic Chemistry Research Group, Department of Organic and Macromolecular Chemistry, Ghent University Krijgslaan 281-S4 9000 Ghent Belgium annemieke.madder@ugent.be.ORCID https://orcid.org/0000-0003-0179-7608
Bruno PaganoDepartment of Pharmacy, University of Naples Federico II Via D. Montesano 49 80131 Naples Italy bruno.pagano@unina.it.ORCID https://orcid.org/0000-0002-7716-9010

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G-quadruplexes (G4s) are non-canonical DNA structures enriched in gene promoters and involved in transcriptional regulation, making them attractive drug targets, albeit difficult to target individually with high specificity due to their structural similarity. In the human

Identifiers

PMID42852091
PMCPMC13648328

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.