ArticleAdvanced nanobiomed research2025
Hydrophilic Particles Exit While Hydrophobic Particles Persist Following In Vivo Biodegradation of Nanoparticle-Laden Polymeric Devices.
Article in Advanced nanobiomed research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Longitudinally monitoring biomedical devices postimplantation can improve patient outcomes by allowing targeted intervention during healing. Most polymeric devices are not visible via biomedical imaging technologies. Incorporation of nanoparticle contrast agents into polymer matrices creates imageable devices, but understanding and controlling nanoparticle clearance from the implant site after polymer degradation is needed for clinical translation. To achieve homogeneous distribution throughout biomedical devices, nanoparticle surface chemistry, particularly hydrophobicity, is often manipulated to generate stable suspensions during manufacture. As nanoparticle surface chemistry is a key parameter determining blood circulation, the effects of nanoparticle hydrophilicity on tissue clearance of nanoparticles from implant sites following polymeric device degradation are investigated. Hydrophilic and hydrophobic radiopaque tantalum oxide (TaO
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