Evidence map›Paper›PMID 42852241›Full record

ReviewFrontiers in immunology2026

The neuroimmune axis in cardiovascular disease: from immune activation to inflammatory resolution.

Kailei Zhang, Zhichao Liu, Yancui Zhang, Yang Yang, Zexin Ding, Sitong Meng, Limin Qin, Luchang Yin, Jinhong Chen

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kailei Zhang *School of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong, China.
Zhichao Liu *School of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong, China.
Yancui ZhangSchool of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong, China.
Yang YangSchool of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong, China.
Zexin DingSchool of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong, China.
Sitong MengSchool of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong, China.
Limin QinDepartment of Cardiovascular, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong, China.
Luchang YinDepartment of Cardiovascular, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong, China.
Jinhong ChenSchool of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases (CVDs) are driven not only by hemodynamic and metabolic stress but also by persistent sterile inflammation and defective resolution. Neuroimmune regulation has emerged as an important focus in cardiovascular research. In this review, we synthesize current evidence on the neuroimmune axis in CVDs and highlight how dysregulated autonomic immune communication promotes persistent inflammation, defective resolution, and adverse cardiovascular remodeling. We further emphasize that the neuroimmune axis may influence not only inflammatory activation but also the transition toward resolution and tissue repair, with its effects likely depending on disease stage and inflammatory context. Targeting neuroimmune pathways may help restore the temporal control of inflammation and promote cardiovascular resolution.

Indexed as

Cardiovascular DiseasesInflammationNeuroimmunomodulationAnimalsAutonomic Nervous SystemCardiovascular SystemHumansautonomic nervous systemcardiovascular diseasesimmunopharmacologyinflammatory resolutionneuroimmune axissterile inflammation

Identifiers

PMID42852241
PMCPMC13647745

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.